SAS is definitely a great tool for your project. Have you started your analysis, or are you new to SAS? As far as asking "is there a significant difference between...", you can test these statistical hypotheses using SAS. A great reference would be this paper by Art Carpenter. For regression, I would recommend you start by reading through Regression with SAS, a free eBook from UCLA. They explain many SAS concepts well, and have code examples. There's also a great page on sasCommunity.org about PROC REGRESSION with various model types. Another book I just found is A Handbook of Statistical Analyses Using SAS. It looks to go through some good examples in detail. If you put some work into the code and come up with specific questions or issues, I am more than happy to help more.
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