If I'm understanding correctly, I don't think you want to use Drop=Y in either of these situations. That is removing the variable from the data set for all subsequent nodes. For the two target situation, as long as you are not using Target1 as an input when modeling Target2 and vice-versa, you can set them both as Target variables, then in the modeling nodes, set Use=Yes to the one you want to use as the target and Use=No to the other. If you do want to use them as inputs when modeling the other one, you can use a Metadata node to change the two targets between target/input and input/target, if that makes sense. For the other situation where you want to keep variables but not include them in the model, you can either set them as Role=Rejected to begin with, or as Role=Input with Use=No in whatever nodes you want to exclude them from.
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