Hi KC, Some answers: If the p-value of the interaction term is > 0.05 indicates the change for all levels of var1 is no difference. A non-significant interaction, but significant main effects, implies that the differences between the levels of var1 is the same at all times, and that the differences between levels of time is the same for all levels of var1. Therefore, the best estimates of effects are the marginal means (main effect means). Does each of the significant simple difference tests by var1 reflect from the significant main time effect? Yes, that is what is being shown. Also, is it still sensible to quantify the simple differences and 95% C.I. on the original scale as you previously posted here While you can report these, the marginal differences are probably more meaningful. Try adding the following to your code: lsmeans time var1/diff cl ilink; to get the marginal means and differences. Steve Denham
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