Another benefit to registering tables in metadata, so that they can be used by metadata centric applications like SAS Data Integration Studio etc, is to be able to answer lineage questions - such as where is this table used downstream and where does it come from upstream. Features such as SAS DI Studio Impact Analysis, the BI Lineage Plug-in and the Relationship Reporting Tools all rely on metadata to be able to provide these valuable insights.
Of course once they are registered in metadata they need to be maintained in metadata (such as updating metadata when the table structure changes). For this reason, if you are not using metadata centric applications, and do not need the various benefits already mentioned in this thread, you may decide not to register them in metadata. For example some sites may have some free-for-all libraries for SAS Enterprise Guide users where the turnover in tables and table structures is so high that, given those tables might only be used by those EG users, the administrators avoid the overhead of maintaining metadata registrations for those tables.
... View more