I know this is a late reply but I recently had this problem and found my issue. I am using SAS EG and ran part of a macro but didn't run the %mend. I then went to run all of my code and got the "NOTE 49-169" issue. SAS doesn't fully dump it's memory so the unbalance of not having %mend creates the note/error. This is why closing the program and then opening and re-running the program "fixes" the problem. A quick solution is to only run the line "%mend" which will generate an error. Ignore the error. Then try re-running all of your code and there should be no issues.
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