@MichaelL_SAS Thank you for your response, it is appreciated. It is indeed true that NDE is bigger than TDE. However, both NDE and NIE are significant. Theoretically, does this mean that the relationship between X (sex) en Y (dementia) is positively explained through the NDE, and negatively explained through NIE (mediator =macrovascular complications)? We already found that females had higher risk of dementia, and macrovascular complications also increase dementia. Am I right that in other words the NIE being negative would mean that less women have macrovascular disease, resulting in that the indirect natural effect is negative and does therefore decrease dementia risk for females through this path? Or does it just mean that it the higher risk of dementia is not explained by the mediator, because it only says something for males in this case. Thank you
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