two sample proportion equivalence test

[Peter_Y]

Hello:

   I want to do a sample size calculation for a two proportion equivalence test to show two drugs are not different. According to this link, 

http://support.sas.com/kb/50/700.html

SAS does not implement this in proc power. 

Does anyone know a work around? Do I need to implement it myself?

Thanks,

Peter

[SteveDenham]

The usage note you refer to is from 2013, and there have been improvements to PROC POWER.  In the SAS/STAT14.1 documentation located here:

http://support.sas.com/documentation/cdl/en/statug/68162/HTML/default/viewer.htm#statug_power_syntax...

there is substantial material related to two sample equivalence and inferiority/superiority testing.

Steve Denham

[sbxkoenk]

I think this paper will give you the answer:

Paper SAS1911-2015

Equivalence and Noninferiority Testing Using SAS/STAT® Software

John Castelloe and Donna Watts, SAS Institute Inc.

http://support.sas.com/resources/papers/proceedings15/SAS1911-2015.pdf

The whole paper (23 pages) is worth reading but you can directly go to

PROPORTIONS, RISK DIFFERENCES, AND RELATIVE RISKS (page 9)

and

Power and Sample Size Analysis for Proportions, Risk Differences, and Relative Risks (page 11)

Good luck,

Koen

[Ksharp]

Or you could data simulation:

http://blogs.sas.com/content/iml/2013/06/05/simulation-power-curve.html

http://blogs.sas.com/content/iml/2013/05/30/simulation-power.html