Hello,
We are designing a cross-over repeated measures design. Participants will have all 4 treatments at four different sessions. During each session, samples will be collected over several time points for 2 hrs.
Is there a SAS procedure for such calculation?
Thank you!
Are you asking for a SAS procedure creating your design or how to analyse the data you gather.
For creating the design: If you've got SAS/Stat then Proc Plan could eventually be useful for you.
Hello,
Thank you for your response. This is helpful. But I have two questions:
1) Is this proc necessary when there is a washout period? Meaning that a carry-over effect is null or minimized?
2) Is there a proc to calculate sample size?
Thanks,
PROC POWER will calculate sample sizes, not sure if your crossover design can be accommodated, but there's an example here:
I'll also move this to the statistical forum.
IME, whenever you start getting into customized trial designs, simulations are the best method to determine your sample size using a bootstrap approach.
@ANKH1 wrote:
Hello,
We are designing a cross-over repeated measures design. Participants will have all 4 treatments at four different sessions. During each session, samples will be collected over several time points for 2 hrs.
Is there a SAS procedure for such calculation?
Thank you!
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