Hi:
For information on SAS/Graph and customization using SAS/Graph statements and using device drivers and other GOPTIONS, then yes, you will have to delve into the world of SAS/Graph documentation.
For ODS REGION/ODS LAYOUT information-- that capability is still experimental and your best bet for information on the usage is to look at SUGI papers, user-group papers or to contact Tech Support. ODS LAYOUT is discussed in this Tech Support document:
http://support.sas.com/techsup/technote/ts659/ts659.html
In that document, it points you to this site for further information:
http://support.sas.com/rnd/base/topics/odsprinter/new9.html#LAYOUT
I could not find any information in either of these documents regarding limitations on the kind of device driver that can be used with ODS REGION/ODS LAYOUT.
Technical Support could tell you for sure how to use ODS LAYOUT/ODS REGION. If you really want to use ODS LAYOUT/ODS REGION and it turns out that you need to use the "non client-side drivers" (like SASPRTC or PNG or GIF or JPEG) instead of ACTIVEX or ACTXIMG, then you CAN customize the graphs with SAS/Graph statements. There is extensive (and award-winning) SAS/Graph documentation that outlines how to customize every aspect of your graph content.
Good luck!
cynthia