Hi, Sir Issue 1: I apologized for issue 1 which making you were confused. Due to data came from my client, I was worried about legal issue if I posted full data. Therefore, I randomly selected some of data at beginning and used part of data in unbalanced.csv. Issue 2: Due to we use Phoenix/WinNonlin for data analysis which applying mixed effects modeling, I am trying using SAS to reproduce the result (T1_TOST and T2_TOST) and I am first time to use ttest for such data so I am not sure how the procedure will handle missing data. Issue 3: I also apologized for misunderstanding, I am sure that I am trying to compare treatment, not the periods, I just used period as variable to indicate what drug was administered in which period. Issue 4: Due to a=0.1 is used as significant level for bioequivalence analysis, therefore, I also used here. I finally work out my analysis by using proc Mixed, thank you for your reply and suggestion, I've learned a lot here.
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