Hi, I tried to figure out what can be the reason that in proc glimmix using the same ML method results different estimate and variance depending on the optimization technic. The model uses two fixed effects, two random effects and one dummy (class) variable. In both scenarios I used the Laplace method, but different optimization technic (Newton-Raphson, quasi-Newton). proc glimmix data = data method=LAPLACE; class dummy random1 random2; model flag (event ='1') = fixed1 fixed2 dummy /link=probit dist=binomial solution or; output out=glimmixout pred( blup ilink)=PredProb pred(noblup ilink)=PredProd_PA; random int /subject= random1 solution; random int /subject= random2 solution; nloptions om=newrap; run; proc glimmix data = data method=LAPLACE; class dummy random1 random2; model flag (event ='1') = fixed1 fixed2 dummy /link=probit dist=binomial solution or; output out=glimmixout pred( blup ilink)=PredProb pred(noblup ilink)=PredProd_PA; random int /subject= random1 solution; random int /subject= random2 solution; nloptions om=quanew; run; The results are slightly different: Newton-Raphson: Intercept _ -2.65210 0.1795 8 -14.77 0.0000004336 fixed1 _ -.631697 0.01484 201E3 -42.56 <.0000000001 fixed2 _ -.097351 0.01102 201E3 -8.83 <.0000000001 Dummy 1 -.775746 0.09144 201E3 -8.48 <.0000000001 Dummy 2 -.677288 0.05578 201E3 -12.14 <.0000000001 Dummy 3 -.422331 0.03932 201E3 -10.74 <.0000000001 Dummy 4 0.071574 0.02895 201E3 2.47 0.0134390943 Dummy 5 0.800703 0.03233 201E3 24.77 <.0000000001 Dummy 6 1.728605 0.07865 201E3 21.98 <.0000000001 Dummy 7 0.000000 . . . . Quasi-Newton: Intercept _ -2.65845 0.1816 8 -14.64 0.0000004659 fixed1 _ -.632236 0.01485 201E3 -42.58 <.0000000001 fixed2 _ -.097346 0.01102 201E3 -8.83 <.0000000001 Dummy 1 -.774482 0.09140 201E3 -8.47 <.0000000001 Dummy 2 -.677044 0.05579 201E3 -12.13 <.0000000001 Dummy 3 -.421267 0.03932 201E3 -10.72 <.0000000001 Dummy 4 0.071657 0.02896 201E3 2.47 0.0133518470 Dummy 5 0.800642 0.03233 201E3 24.76 <.0000000001 Dummy 6 1.728683 0.07866 201E3 21.98 <.0000000001 Dummy 7 0.000000 . . . . Is there any reason why I don’t get the same results for the two scenarios? Thanks
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