Yes, thank you very much for your response. Analyzing incidental tumors and fatal tumors separately is no longer an issue. However, relevant statistical analysis guidelines for carcinogenicity studies stipulate that tumors falling into both the incidental and fatal categories must be analyzed separately as incidental cases and fatal cases. The results of these two analyses should then be combined to derive a single p-value. After reviewing extensive literature, I remain unclear on how to perform this combined p-value calculation. I kindly request your guidance on implementing this p-value computation. The relevant guideline is titled: FDA (2001) Guidance for Industry Statistical Aspects of the Design, Analysis, and Interpretation of Chronic Rodent Carcinogenicity Studies of Pharmaceuticals ... View more