Hi Sorry for bringing this into an old post, but i have read the previous explanation and grab some insight on the mean model. At the moment i am struggling with defining the LSMESTIMATE statement. Below is my syntax:     PROC GLIMMIX DATA=dataa; CLASS SEASON DAYS AGE ANIMAL_ID; MODEL RESPONSE= SEASON*DAYS*AGE/ SOLUTION DDFM=RES; RANDOM ANIMAL_ID; RUN; QUIT;   I am not so sure how to define it especially from the model with 3 fixed factors.   LSMESTIMATE SEASON*DAYS*AGE ?? I also attached my data set if maybe i am missing something out.   Help please. Regards, Education ... View more