Hi All,   I am trying to pre-specify / get a better understanding of how to perform a multivariate (3 or 4 outcomes) longitudinal repeated measures analysis where outcomes are measured daily over many months.    If I had just a few time points then my research has guided me towards a random coefficient models in PROC MIXED such as that specified in “Analyzing Multivariate Longitudinal Data Using SAS® “.   But I am struggling to find details of models to account for "continuous" time.  I have seen mention of modelling time as a continuous variable, or the use of a splined covariance structure.  Would someone mind pointing me in the direction of some appropriate literature in relation to these, or other suggested methodologies please.   Thank you. ... View more