Hi Reeza Thank you for fast reply! I do not know how to explain my problem, but I'll try with an example: 1) I need to see if there is change in variable 'A1_patological' from 'time 1' to 'time 2' to 'time 3' to 'time 4' to 'time 5' in total and afterwards stratified by randomisation code (0 or 1). My participants does not necessary have measured A1 at all 5 time points. 2) as above, just to see if variable 'A1' (continuous value) is changing (raising or falling) at this 5 time points in total and afterwards stratified by randomisation code (0 or 1). I suppose that I can present data as a diagram. I hope the data set is visible now with a copy and paste from Excel-file. Wasn't it that I should do? Sincerely Mignon ParticipantID_and_time Randomisation_code P_pr_min A1 A1_patological A2 A2_patological A3 A3_patological A4 A4_patological A5 A5_patological A_max_dur A_max_dur_patological TIME ID1time1 0 73 -0,25 1 -0,25 1 -3,25 1 0 0 0 0 80 1 1 ID1time2 0 77 -0,25 1 -0,5 1 -4 1 0 0 0 0 100 1 2 ID1time3 0 88 -0,25 1 -0,25 1 0 0 0 0 -0,25 1 40 1 3 ID1time4 0 144 -0,5 1 -0,25 1 -2,5 1 0 0 -0,25 1 60 1 4 ID1time5 0 96 -0,5 1 0 0 -2 1 0 0 -0,25 1 60 1 5 ID2time1 0 93 0 0 -0,512820513 0 -0,769230769 1 -13,84615385 1 0 0 61,53846154 1 1 ID2time2 0 81 0 0 0 0 0 0 -7,435897436 1 -0,769230769 1 102,5641026 1 2 ID3time1 0 79 -0,5 1 -0,25 1 0 0 0 0 -0,25 1 80 1 1 ID3time2 0 54 0 0 -0,25 1 -1,25 1 -3 1 0 0 80 1 2 ID3time5 0 67 0 0 0 0 -1 1 -2,5 1 0 0 20 0 5 ID4time1 1 114 . . . . . . . . . . 30 1 1 ID4time4 1 91 0 0 -0,75 1 -1,25 1 -7 1 0 0 40 1 4 ID4time5 1 82 0 0 -1,25 1 -4 1 0 0 0 0 40 1 5 ID5time1 0 85 -0,5 1 -0,5 1 -0,25 1 0 0 -0,5 1 80 1 1 ID5time2 0 59 0 0 -1 1 -1 1 0 0 0 0 80 1 2 ID5time3 0 89 0 0 -1 1 -0,5 1 0 0 0 0 60 1 3 ID5time4 0 104 0 0 -1,25 1 0 0 -7,5 1 0 0 60 1 4
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