Hi Rick, Thanks for your helpful response. I came back to this problem again yesterday and the simulated data very much helped me visualise the problem. To give clarity with respect to using the mean adherence, we have a scenario where in one treatment group patients are asked to take multiple drugs in a 24 hour period and so for each day daily adherence would yield a percentage and not a 0 or 1. So for example, if a patient is required to take 3 drugs in a 24 hour period then, if they take one this yields a daily percentage of 33.34%, 2 then 66.67% and so on. The interest lies in calculating the mean daily adherence for each patient. This is why we originally approached the problem as a continuous variable. Regards, Lynn ##- Please type your reply above this line. Simple formatting, no attachments. -##
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