Hi Everyone, Among certain cancer patients, I am running a cox model to examine Effect of Treatment Era (year of cancer diagnosis) on Hazard of developing cardiovascular disease (CVD) accounting for Competing Risk of Death. Actually, it is the Fine-Gray model. The problem is that Treatment Era (year of cancer diagnosis) violated the PH assumption. Since it is our main interest variable, we can not stratify by it. I have checked the interaction between treatment Era (year of cancer diagnosis) and chemotherapy/ radiation, none of them is significant. The cumulative incidence of CVD between 1990-2007 is higher than 2008-2014 for sure. So my question is for the Fine-Gray model, does PH assumption matter? Can I ignore it? If we can not ignore, anything else can I do? I feel the year of cancer diagnosis is kind of time variable... Any suggestion will be appreciated! Thanks a lot!
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