I am speculating here so bear with me. The EG guys can correct if I miss something.
EG is a .NET/C# app (I am a SAS and C# dev so I kind of know how this works). When you make changes to an EG project, it saves them to the in-memory object (classes). When you save, it has to serialize them to XML. When you open a project, it deserializes them back to the objects. Any time you are serializing a large object, it can go wrong. Shouldn't, but it can. depending on what happens in the I/O. Especially true over a network connection. I suspect something blipped in the serialization.
You really need to make the project smaller. I have never seen an EG project of that size and I look at them a lot, especially in their raw form. I rarely use EG as an application, mainly deal with the EG zip file or making EG add-ins. If you have data stored in the project (which I suspect), move it elsewhere.
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