For your one question, the link is definitely not the same as a transformation. The distinction can be subtle, but important. The link is a function of the expected value (i.e., mean), not a function of the response variable; in contrast, a transformation is a function of the response variable (not the mean). Say, z = 1/time (the transformation you mention). We can also write f(time) = 1/time. Then in GLIMMIX (or MIXED), one is modeling (without random effects) E(z) = E(f(time)) = E(1/time) = X.beta Here, E(.) is the expectation. You are dealing with means of the transformation. Back-transforming does NOT give you the mean of time, but a shifted value away from the mean. A link can be written generically as g(mu), which in your case is g(E(time)), a function of the expected value. So, with link=inverse, you are modeling g(E(time)) = 1/E(time) = 1/mu = X.beta Note that the expectation in the first case is of the function of time, but with the link, one has a function of the expectation. The back transformation of the link, known as the "inverse link" (a term unrelated to the use of 1/mu as the link), gives the actual expected value of time (your response variable). In general, use of link functions is preferred because one is working with means of the original response variable. With that said, inverses are tricky for modeling purposes, whether as data transformations or links. These can be especially problematical when the response varies greatly, with some points very close to 0. This is not the the situation with your data, apparently. There are lots of reasons why one can have problems with convergence. Can't tell based on your post. Maybe the algorithm is getting close or is stuck at a saddle point in the log-likelihood response surface. You could try some other optimization methods: NLOPTIONS TECH = ; You could try QUANEW or TRUREG or NRRIDG for technique; there are others listed in the user's guide. If you are willing to move away from normal distributions, you have many possibilities. You mentioned that you have unequal variances. This is an essential property of variables with gamma or exponential distributions, or many other distributions. You could model the data with a gamma distribution, with time as your response variable (not 1/time). In this case the default link is log. "Inverse link" gives you expected time values.
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