Proc Mixed and family wise error

[zz109]

I used Proc Mixed statements to run multiple path analyses to test the direct and indirect effects of my two IVs and two mediators on three DVs (2x2 within-between mixed experimental design).

One of the p-values associated with these paths was close to .05, and the reviewer raised a concern of experimental-wise type 1 error. I think family-wise type 1 error should be the concern of this case. I wonder whether the Proc Mixed procedures provide any statement or (default) function to adjust p-values to control the family-wise type1 error issue. Thanks a lot for any suggestions and help!

[sbxkoenk]

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@zz109 wrote:

I wonder whether the Proc Mixed procedures provide any statement or (default) function to adjust p-values to control the family-wise type1 error issue. Thanks a lot for any suggestions and help!

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I do not think so.
The p-values in PROC MIXED are "raw" (i.e. unadjusted).

Maybe you can have a look into MULTTEST Procedure.
SAS® 9.4 and SAS® Viya® 3.5 Programming Documentation | SAS 9.4 / Viya 3.5
SAS/STAT User's Guide
The MULTTEST Procedure
p-Value Adjustments
Familywise Error Rate Controlling Adjustments
https://go.documentation.sas.com/doc/en/pgmsascdc/9.4_3.5/statug/statug_multtest_details11.htm

Cheers,

Koen

[SteveDenham]

Could you post the code you are using?  I believe you can get family-wise adjustments of p values for differences between lsmeans using the ADJUST= option in the LSMEANS/LSMESTIMATE/ESTIMATE/CONTRAST statement, but it will depend on how you frame the comparisons.  It may also require a GROUP= option for the random or repeated effect.

SteveDenham