I am analyzing a data set.
I have 3 x 4 x 4 design.
Three treatments with four doses for each treatment and four sample time points for each dose. The samples are individual samples at different times (not repeated samples).
I am using Proc Mixed as under
proc mixed;
class group dose time;
model e=dose|group|time/ outp=new;
random
If the observations are independent--if there is no clustering, or blocking, or repeated measures on the same subject--and if the homogeneity of variances assumption is met, then there is only one source of variance in your design (which will be estimated as residual variance) and you do not need a RANDOM statement. The MIXED procedure works just fine without a RANDOM statement.
Many thanks. It was of great help.
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