PROC GLM: Estimate statement

[yw2757]

When reading paper "https://www.lexjansen.com/pharmasug/2011/SAS/PharmaSUG-2011-SAS-SP01.pdf"

I am confused about the following highlighted part.

How to set these numbers? For instance, "mean of drug 1 is the same as the mean of drug 2 for disease 2" ?

Any way to understand this step?

Thank you!

[StatDave]

See this note that describes how values are determined for models involving interactions. Pay particular attention to the Introduction which tells you to avoid using the ESTIMATE and CONTRAST statements when the equivalent can much more easily be done with statements like LSMEANS, SLICE or LSMESTIMATE can be used. Many examples are provided in this note and in other notes that you can find at support.sas.com.