Here is one way. hth.
/* test data */
data one;
old = "asdgdfgdg";
run;
/* create a new var replacing dg with YY in old */
data two;
set one;
length new $9;
new = prxchange("s|dg|YY|", -1, old);
run;
/* check */
proc print data=two;
run;
/* on lst
Obs old new
1 asdgdfgdg asYYdfgYY
*/
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