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Sir,thanks a lot for this help.I am now trying to fix where it does not match with the original result.I will post if I face any challenge.
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Sir ,I have fixed all the issues and logic almost.The below are the cases where I tried hard but did not resolve the problem.If you can look into these once that would be a great help for me.
data have; length patient_id $15. drug_name $50. ; input patient_id (drug_name drug_type) ($) (start end) (: date11.); format start end date9.; cards; 14526897 Interferon_Alfa_2b Non_core 11-Aug-14 11-Aug-14 14526897 Interferon_Alfa_2b Non_core 12-Aug-14 12-Aug-14 14526897 Interferon_Alfa_2b Non_core 13-Aug-14 13-Aug-14 14526897 Interferon_Alfa_2b Non_core 14-Aug-14 14-Aug-14 14526897 Interferon_Alfa_2b Non_core 15-Aug-14 15-Aug-14 14526897 Interferon_Alfa_2b Non_core 18-Aug-14 18-Aug-14 14526897 Interferon_Alfa_2b Non_core 19-Aug-14 19-Aug-14 14526897 Interferon_Alfa_2b Non_core 20-Aug-14 20-Aug-14 14526897 Interferon_Alfa_2b Non_core 21-Aug-14 21-Aug-14 14526897 Interferon_Alfa_2b Non_core 22-Aug-14 22-Aug-14 14526897 Interferon_Alfa_2b Non_core 25-Aug-14 25-Aug-14 14526897 Interferon_Alfa_2b Non_core 26-Aug-14 26-Aug-14 14526897 Interferon_Alfa_2b Non_core 27-Aug-14 27-Aug-14 14526897 Interferon_Alfa_2b Non_core 28-Aug-14 28-Aug-14 14526897 Interferon_Alfa_2b Non_core 2-Sep-14 2-Sep-14 14526897 Interferon_Alfa_2b Non_core 3-Sep-14 3-Sep-14 14526897 Interferon_Alfa_2b Non_core 3-Sep-14 30-Sep-14 14526897 Interferon_Alfa_2b Non_core 4-Sep-14 4-Sep-14 14526897 Interferon_Alfa_2b Non_core 5-Sep-14 5-Sep-14 14526897 Interferon_Alfa_2b Non_core 8-Sep-14 8-Sep-14 14526897 Interferon_Alfa_2b Non_core 9-Sep-14 9-Sep-14 14526897 Interferon_Alfa_2b Non_core 13-Nov-14 10-Dec-14 14526897 Interferon_Alfa_2b Non_core 23-Dec-14 19-Jan-15 14526897 Interferon_Alfa_2b Non_core 9-Jan-15 5-Feb-15 14526897 Interferon_Alfa_2b Non_core 27-Feb-15 26-Mar-15 14526897 Interferon_Alfa_2b Non_core 17-Jun-15 14-Jul-15 897452634 Cisplatin Non_core 19-Jan-16 19-Jan-16 897452634 Dacarbazine Non_core 19-Jan-16 19-Jan-16 897452634 Ipilimumab Core 19-Jan-16 19-Jan-16 897452634 Vinblastine Non_core 19-Jan-16 19-Jan-16 897452634 Cisplatin Non_core 20-Jan-16 20-Jan-16 897452634 Vinblastine Non_core 20-Jan-16 20-Jan-16 897452634 Cisplatin Non_core 21-Jan-16 21-Jan-16 897452634 Vinblastine Non_core 21-Jan-16 21-Jan-16 897452634 Vinblastine Non_core 22-Jan-16 22-Jan-16 897452634 Cisplatin Non_core 9-Feb-16 9-Feb-16 897452634 Dacarbazine Non_core 9-Feb-16 9-Feb-16 897452634 Ipilimumab Core 9-Feb-16 9-Feb-16 897452634 Vinblastine Non_core 9-Feb-16 9-Feb-16 897452634 Cisplatin Non_core 10-Feb-16 10-Feb-16 897452634 Vinblastine Non_core 10-Feb-16 10-Feb-16 897452634 Cisplatin Non_core 11-Feb-16 11-Feb-16 897452634 Vinblastine Non_core 11-Feb-16 11-Feb-16 897452634 Vinblastine Non_core 12-Feb-16 12-Feb-16 897452634 Cisplatin Non_core 1-Mar-16 1-Mar-16 897452634 Dacarbazine Non_core 1-Mar-16 1-Mar-16 897452634 Ipilimumab Core 1-Mar-16 1-Mar-16 897452634 Vinblastine Non_core 1-Mar-16 1-Mar-16 897452634 Cisplatin Non_core 2-Mar-16 2-Mar-16 897452634 Vinblastine Non_core 2-Mar-16 2-Mar-16 897452634 Cisplatin Non_core 3-Mar-16 3-Mar-16 897452634 Vinblastine Non_core 3-Mar-16 3-Mar-16 897452634 Cisplatin Non_core 22-Mar-16 22-Mar-16 897452634 Dacarbazine Non_core 22-Mar-16 22-Mar-16 897452634 Ipilimumab Core 22-Mar-16 22-Mar-16 897452634 Vinblastine Non_core 22-Mar-16 22-Mar-16 897452634 Cisplatin Non_core 23-Mar-16 23-Mar-16 897452634 Vinblastine Non_core 23-Mar-16 23-Mar-16 897452634 Cisplatin Non_core 24-Mar-16 24-Mar-16 897452634 Vinblastine Non_core 24-Mar-16 24-Mar-16 587956 Ipilimumab Core 31-May-13 22-Aug-13 587956 Ipilimumab Core 3-Jun-13 3-Jun-13 587956 Dacarbazine Non_core 4-Jun-13 4-Jun-13 587956 Ipilimumab Core 4-Jun-13 4-Jun-13 587956 Ipilimumab Core 14-Jun-13 14-Jun-13 587956 Dacarbazine Non_core 1-Jul-13 1-Jul-13 587956 Ipilimumab Core 1-Jul-13 1-Jul-13 587956 Ipilimumab Core 3-Jul-13 3-Jul-13 587956 Dacarbazine Non_core 30-Jul-13 30-Jul-13 587956 Ipilimumab Core 30-Jul-13 30-Jul-13 587956 Dacarbazine Non_core 27-Aug-13 27-Aug-13 587956 Ipilimumab Core 27-Aug-13 27-Aug-13 587956 Ipilimumab Core 14-Oct-13 14-Oct-13 587956 Dacarbazine Non_core 15-Oct-13 15-Oct-13 9874526 Vemurafenib Core 9-May-13 7-Jun-13 9874526 Vemurafenib Core 11-Jun-13 10-Jul-13 9874526 Vemurafenib Core 13-Jun-13 13-Jun-13 9874526 Vemurafenib Core 11-Jul-13 11-Jul-13 9874526 Vemurafenib Core 13-Jul-13 11-Aug-13 9874526 Vemurafenib Core 13-Aug-13 13-Aug-13 9874526 Dabrafenib Core 19-Aug-13 17-Sep-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Aug-13 17-Sep-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Sep-13 10-Sep-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-13 17-Oct-13 9874526 Dabrafenib Core 23-Sep-13 22-Oct-13 9874526 Dabrafenib Core 8-Oct-13 8-Oct-13 9874526 Dabrafenib Core 21-Oct-13 19-Nov-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 21-Oct-13 19-Nov-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Nov-13 6-Nov-13 9874526 Dabrafenib Core 18-Nov-13 17-Dec-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Nov-13 17-Dec-13 9874526 Trametinib_Dimethyl_Sulfoxide Core 5-Dec-13 5-Dec-13 9874526 Dabrafenib Core 23-Dec-13 21-Jan-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Dec-13 21-Jan-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Jan-14 2-Jan-14 9874526 Dabrafenib Core 20-Jan-14 18-Feb-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Jan-14 18-Feb-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Feb-14 12-Mar-14 9874526 Dabrafenib Core 18-Feb-14 19-Mar-14 9874526 Dabrafenib Core 25-Feb-14 25-Feb-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 1-Apr-14 30-Apr-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 6-May-14 6-May-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 7-May-14 5-Jun-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Jun-14 3-Jun-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Jun-14 5-Jul-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 8-Jul-14 6-Aug-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 17-Jul-14 17-Jul-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 7-Aug-14 5-Sep-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Aug-14 20-Aug-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Sep-14 2-Oct-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-14 18-Sep-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Oct-14 31-Oct-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Oct-14 16-Oct-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 4-Nov-14 3-Dec-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 12-Nov-14 12-Nov-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 15-Dec-14 13-Jan-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Dec-14 16-Dec-14 9874526 Trametinib_Dimethyl_Sulfoxide Core 13-Jan-15 11-Feb-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Feb-15 10-Feb-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Feb-15 20-Mar-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Mar-15 19-Mar-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 14-Apr-15 13-May-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Apr-15 23-Apr-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 14-May-15 12-Jun-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Jun-15 10-Jul-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Jun-15 30-Jun-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 28-Jul-15 28-Jul-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 29-Jul-15 27-Aug-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-15 26-Aug-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Sep-15 1-Oct-15 9874526 Vemurafenib Core 2-Sep-15 1-Oct-15 9874526 Vemurafenib Core 24-Sep-15 24-Sep-15 9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Sep-15 29-Oct-15 9874526 Vemurafenib Core 23-Oct-15 21-Nov-15 9874526 Cobimetinib Core 4-Dec-15 9-Jan-16 9874526 Cobimetinib Core 23-Dec-15 23-Dec-15 9874526 Cobimetinib Core 4-Jan-16 9-Feb-16 9874526 Ipilimumab Core 3-Feb-16 3-Feb-16 9874526 Nivolumab Core 3-Feb-16 3-Feb-16 874512399 Dabrafenib Core 25-Apr-14 24-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14 874512399 Dabrafenib Core 2-Jun-14 1-Jul-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14 874512399 Dabrafenib Core 5-Aug-14 3-Sep-14 874512399 Dabrafenib Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15 874512399 Bevacizumab Non_core 1-May-15 1-May-15 874512399 Bevacizumab Non_core 18-May-15 18-May-15 874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15 874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15 874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15 874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15 874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15 874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15 874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15 874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15 874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15 874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15 874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15 874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15 874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15 874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16 874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16 874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16 874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16 874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16 874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16 74521369845 Cisplatin Non_core 29-Jul-14 29-Jul-14 74521369845 Dacarbazine Non_core 29-Jul-14 29-Jul-14 74521369845 Vinblastine Non_core 29-Jul-14 29-Jul-14 74521369845 Cisplatin Non_core 30-Jul-14 30-Jul-14 74521369845 Vinblastine Non_core 30-Jul-14 30-Jul-14 74521369845 Cisplatin Non_core 31-Jul-14 31-Jul-14 74521369845 Vinblastine Non_core 31-Jul-14 31-Jul-14 74521369845 Cisplatin Non_core 26-Aug-14 26-Aug-14 74521369845 Dacarbazine Non_core 26-Aug-14 26-Aug-14 74521369845 Ipilimumab Core 26-Aug-14 26-Aug-14 74521369845 Vinblastine Non_core 26-Aug-14 26-Aug-14 74521369845 Cisplatin Non_core 27-Aug-14 27-Aug-14 74521369845 Vinblastine Non_core 27-Aug-14 27-Aug-14 74521369845 Cisplatin Non_core 28-Aug-14 28-Aug-14 74521369845 Vinblastine Non_core 28-Aug-14 28-Aug-14 74521369845 Cisplatin Non_core 16-Sep-14 16-Sep-14 74521369845 Dacarbazine Non_core 16-Sep-14 16-Sep-14 74521369845 Ipilimumab Core 16-Sep-14 16-Sep-14 74521369845 Vinblastine Non_core 16-Sep-14 16-Sep-14 74521369845 Cisplatin Non_core 17-Sep-14 17-Sep-14 74521369845 Vinblastine Non_core 17-Sep-14 17-Sep-14 74521369845 Cisplatin Non_core 18-Sep-14 18-Sep-14 74521369845 Vinblastine Non_core 18-Sep-14 18-Sep-14 74521369845 Vinblastine Non_core 19-Sep-14 19-Sep-14 74521369845 Cisplatin Non_core 7-Oct-14 7-Oct-14 74521369845 Dacarbazine Non_core 7-Oct-14 7-Oct-14 74521369845 Ipilimumab Core 7-Oct-14 7-Oct-14 74521369845 Vinblastine Non_core 7-Oct-14 7-Oct-14 74521369845 Cisplatin Non_core 8-Oct-14 8-Oct-14 74521369845 Vinblastine Non_core 8-Oct-14 8-Oct-14 74521369845 Cisplatin Non_core 9-Oct-14 9-Oct-14 74521369845 Vinblastine Non_core 9-Oct-14 9-Oct-14 74521369845 Vinblastine Non_core 10-Oct-14 10-Oct-14 74521369845 Cisplatin Non_core 28-Oct-14 28-Oct-14 74521369845 Dacarbazine Non_core 28-Oct-14 28-Oct-14 74521369845 Vinblastine Non_core 28-Oct-14 28-Oct-14 74521369845 Cisplatin Non_core 29-Oct-14 29-Oct-14 74521369845 Vinblastine Non_core 29-Oct-14 29-Oct-14 74521369845 Cisplatin Non_core 30-Oct-14 30-Oct-14 74521369845 Vinblastine Non_core 30-Oct-14 30-Oct-14 74521369845 Cisplatin Non_core 2-Dec-14 2-Dec-14 74521369845 Dacarbazine Non_core 2-Dec-14 2-Dec-14 74521369845 Vinblastine Non_core 2-Dec-14 2-Dec-14 74521369845 Cisplatin Non_core 3-Dec-14 3-Dec-14 74521369845 Vinblastine Non_core 3-Dec-14 3-Dec-14 74521369845 Cisplatin Non_core 4-Dec-14 4-Dec-14 74521369845 Vinblastine Non_core 4-Dec-14 4-Dec-14 4526789 Interleukin-2 Core 26-Oct-15 31-Oct-15 4526789 Interleukin-2 Core 27-Oct-15 27-Oct-15 4526789 Interleukin-2 Core 28-Oct-15 28-Oct-15 4526789 Interleukin-2 Core 29-Oct-15 29-Oct-15 4526789 Interleukin-2 Core 30-Oct-15 30-Oct-15 4526789 Interleukin-2 Core 31-Oct-15 31-Oct-15 4526789 Interferon_Alfa_2b Non_core 2-Nov-15 29-Nov-15 4526789 Interferon_Alfa_2b Non_core 16-Nov-15 20-Nov-15 4526789 Interferon_Alfa_2b Non_core 17-Nov-15 17-Nov-15 4526789 Interferon_Alfa_2b Non_core 18-Nov-15 18-Nov-15 4526789 Interferon_Alfa_2b Non_core 19-Nov-15 19-Nov-15 4526789 Interferon_Alfa_2b Non_core 20-Nov-15 20-Nov-15 4526789 Interferon_Alfa_2b Non_core 7-Dec-15 3-Jan-16 4526789 Interleukin-2 Core 7-Dec-15 11-Dec-15 4526789 Interleukin-2 Core 8-Dec-15 8-Dec-15 4526789 Interleukin-2 Core 9-Dec-15 9-Dec-15 4526789 Interleukin-2 Core 10-Dec-15 10-Dec-15 4526789 Interleukin-2 Core 11-Dec-15 11-Dec-15 4526789 Pembrolizumab Core 30-Mar-16 30-Mar-16 4526789 Pembrolizumab Core 20-Apr-16 20-Apr-16 4526789 Pembrolizumab Core 11-May-16 11-May-16 4526789 Pembrolizumab Core 18-May-16 18-May-16 4526789 Pembrolizumab Core 8-Jun-16 8-Jun-16 4526789 Pembrolizumab Core 29-Jun-16 29-Jun-16 78954526 Dabrafenib Core 25-Apr-14 24-May-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Apr-14 24-May-14 78954526 Dabrafenib Core 30-Apr-14 29-May-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 30-Apr-14 29-May-14 78954526 Dabrafenib Core 29-May-14 27-Jun-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 29-May-14 27-Jun-14 78954526 Dabrafenib Core 25-Jun-14 24-Jul-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-14 24-Jul-14 78954526 Dabrafenib Core 18-Aug-14 16-Sep-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 18-Aug-14 16-Sep-14 78954526 Dabrafenib Core 15-Sep-14 14-Oct-14 78954526 Trametinib_Dimethyl_Sulfoxide Core 15-Sep-14 14-Oct-14 78954526 Ipilimumab Core 9-Oct-14 9-Oct-14 8745120369 Dabrafenib Core 18-Aug-14 16-Sep-14 8745120369 Dabrafenib Core 20-Aug-14 18-Sep-14 8745120369 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-14 24-Sep-14 8745120369 Trametinib_Dimethyl_Sulfoxide Core 23-Sep-14 21-Dec-14 8745120369 Dabrafenib Core 17-Oct-14 14-Jan-15 8745120369 Ipilimumab Core 22-Dec-14 22-Dec-14 ;
For patient id 14526897 - a non core drug Interferon Alfa-2b starts on 11aug2014 and applying 21 days we get lot 1 ends on 9 sep2014.there is no drug use or a new core drug in 60 dyas period after finishing of lot 1 .so lot 2 begins on 13nov2014 apply the same above rule we get lot 2 ends on 26mar2014.And so on.
For patient id 897452634- Non core drug Cisplatin starts on 19jan2016 and apply 21 days and 60 days criteria we get end of latest use core drug is 22mar2016 so lot end here .As per the rule if there is core and non core drug in the lot the end date would be end date of latest use core drug not the end date of of laest use non core drug after apply 21 days and 60 days criteria.
For patient id 587956 - a core drug Ipilumab starts on 31may2013 .applying 21 days and 60 days criteria ,we get end date of latest use core drug is 14oct2015 as lot 1 contains both core and noncore drugs.
For patient id 9874526 - Lot 4 end on 2feb2015 as a new core drug other than lot 5 starts on 3rd feb.As per the overlapping rule if a core drug from previous lot continues after start of current regiemn and it will again start on anytime within 21 days or 60 dyas then this core drug will be added in the current regimen.If a core drug from previous regimen continues after starting of current regimen but it does not start again in 21 or 60 days periods of current regimen then overlapping rule will not be applied.overlapping rule is not aplied for non core drugs.In this current patient id as the non core drug Combimetinib from lot 4 continues after start of lot 4.but as it non core we will not add this in lot 5 but currently it is being added which should not be the case.
For patient id 874512399 - Core drug Dabrafenib starts on 25 april and within 21 days Trametinib Dimethyl Sulfoxide starts and latest use of the core drug is 28may2014. now applying 60 days criteria we get lot 1 ends on 21jan 2015.As per the rule of new lot start ethier there shold be no use of drug within 60 days or there is any new core drug starts within 60 days.Here from end date of lot1 is 21jan2015 with a blank period of more than 60 days.So lot2 starts on 16apr2015 .after applying 21 days criteris we get Bevacizumab starts within 21 days and after applying 60 days criteria there is no core drug found .so lot 2 ends on 16apr2015.To start of lot 3 ,there should be gap of blank 60 days with no drug use or a new core drug other than previous lot should be there .So applying this rule we get Bevacizumab starts on 16june2015 and apply 21 and 60 days criteria ,we get lot 3 ends on 7apr2016(1 day prior to new core core drug ) as a new core drug other than lot3 starts on 8apr2016.Now lot4 begins and apllying rthe same rule we get it ends on 8apr2016.
For patient id 74521369845 - A non core drugs starts on 29july2014 after apllying 21 and 60 days criteria we found a new core drug Ipilumab starts on 26aug20114 so lot 1 ends here.lot 2 starts on 26aug2014.after apllying 21 days we found a non core drug from previous lot contines after or on start of lot 2 and gian starts on within 60 days but we should not include it in lot as for non core drug the overlapping rules are not applied.and after applying 60 days criteria we get end date of latest use core drug is 7oct2014 so lot2 ends here.
For patient id 4526789 - a core drug interlukin-2 starts on 26-oct2015 .after applying 21 days and 60 days criteria ,we end date of latest use core drus is 11 dec2015 as lot 1 is core plus non coreregimen.again as there is no drug in 60 dys period or no new core drug available,so lot 2 starts on 30mar2016 ..and apply the all rule we get lot 2 ends on 29jun2016.
For patient id 78954526 - a core drug dabrafinib starts on 30apr14 .after applying 21 days and 60 criteria we get lot 1 ends on 8 th october as a new core drug other than from the lot 1 starts on 9oct.As per the overlapping rule if a core drug from previous lot continues after start of current regiemn and it will again start on anytime within 21 days or 60 dyas then this core drug will be added in the current regimen.If a core drug from previous regimen continues after starting of current regimen but it does not start again in 21 or 60 days periods of current regimen then overlapping rule will not be applied.Although core drug Dabranib and Trametinib continues after start of lot 2 but any of them did not start again anytime within 21 or 60 days.so it will not be included in lot 2 .but currently it is being included.
For patient id 8745120369 - the same thing as patinet id 78954526
Data i want -
patien_id drug start end
14526897 Interferon Alfa-2b 11AUG2014 09SEP2014
14526897 Interferon_Alfa_2b 13NOV2014 26MAR2015
14526897 Interferon_Alfa_2b 17JUN2015 14JUL2015
897452634 Cisplatin+Dacarbazine+Ipilimumab+Vinblastine 19JAN2016 22MAR2016
587956 Dacarbazine+Ipilimumab 31MAY2013 14OCT2013
9874526 Vemurafenib 09MAY2013 13AUG2013
9874526 Dabrafenib+Trametinib Dimethyl Sulfoxide 19AUG2013 01SEP2015
9874526 Trametinib Dimethyl Sulfoxide+Vemurafenib 02SEP2015 21NOV2015
9874526 Cobimetinib 04DEC2015 02FEB2016
9874526 Ipilimumab+Nivolumab 03FEB2016 03FEB2016
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25APR2014 21JAN2015
874512399 Bevacizumab+Trametinib Dimethyl Sulfoxide 16APR2015 16APR2015
874512399 Bevacizumab 16JUN2015 07APR2016
874512399 Pembrolizumab + Bevacizumab 08APR2016 08APR2016
74521369845 Cisplatin+Dacarbazine+Vinblastine 29JUL2014 25AUG2014
74521369845 Cisplatin+Ipilimumab+Vinblastine 26AUG2014 07OCT2014
4526789 Interferon Alfa-2b+Interleukin-2 26OCT2015 11DEC2015
4526789 Pembrolizumab 30MAR2016 29JUN2016
78954526 Dabrafenib+Trametinib Dimethyl Sulfoxide 25APR2014 08OCT2014
78954526 Ipilimumab 09OCT2014 09OCT2014
8745120369 Dabrafenib+Trametinib Dimethyl Sulfoxide 18AUG2014 21DEC2014
8745120369 Ipilimumab 22DEC2014 22DEC2014
The result I am currently getting -
patien_id drug start end Lot
14526897 Interferon_Alfa_2b 11-Aug-14 26-Mar-15 1
14526897 Interferon_Alfa_2b 17-Jun-15 14-Jul-15 2
897452634 Ipilimumab+Vinblastine+Cisplatin+Dacarbazine 19-Jan-16 24-Mar-16 1
587956 Ipilimumab+Dacarbazine 31-May-13 15-Oct-13 1
9874526 Vemurafenib 9-May-13 13-Aug-13 1
9874526 Dabrafenib+Trametinib Dimethyl Sulfoxide 19-Aug-13 1-Sep-15 2
9874526 Vemurafenib+Trametinib Dimethyl Sulfoxide 2-Sep-15 21-Nov-15 3
9874526 Cobimetinib 4-Dec-15 2-Feb-16 4
9874526 Ipilimumab+Cobimetinib+Nivolumab 3-Feb-16 9-Feb-16 5
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25-Apr-14 21-Jan-15 1
874512399 Trametinib Dimethyl Sulfoxide+Bevacizumab 16-Apr-15 7-Apr-16 2
874512399 Pembrolizumab+Bevacizumab 8-Apr-16 8-Apr-16 3
74521369845 Cisplatin+Dacarbazine+Vinblastine 29-Jul-14 25-Aug-14 1
74521369845 Ipilimumab+Vinblastine+Cisplatin+Dacarbazine 26-Aug-14 4-Dec-14 2
4526789 Interleukin-2+Interferon Alfa-2b 26-Oct-15 3-Jan-16 1
4526789 Pembrolizumab 30-Mar-16 29-Jun-16 2
78954526 Dabrafenib+Trametinib Dimethyl Sulfoxide 25-Apr-14 8-Oct-14 1
78954526 Ipilimumab+Dabrafenib+Trametinib Dimethyl Sulfoxide 9-Oct-14 14-Oct-14 2
8745120369 Dabrafenib+Trametinib Dimethyl Sulfoxide 18-Aug-14 21-Dec-14 1
8745120369 Ipilimumab+Dabrafenib 22-Dec-14 14-Jan-15 2
Thanks in advance.
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The code is producing some results you're not expecting because it is only implementing the rules as I understand them.
e.g. patient_id 14526897 got his/her drug again on Sep 3rd with an expiration date of 30sep14, As such, the sixty day window kept increasing un 26mar15.
for patient_id 897452634, Ipilimumab was the first drug counted as it was a core drug identified within the first 21 days.
As for the ending dates, you'll have to review and understand the code to ensure that your number of days criteria are met. That is the main place where the current code might be wrong.
Art, CEO, AnalystFinder.com
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Sir,thanks for you reply .
patient_id 14526897 the result is correct as you told.
But for patient_id 897452634 ,the end date of the lot it is not correct as it is taking the maximum date non core drug .
Two situations I am not etting the correct output otherwise the code works fine for me .I need to change something in the code to get the desired output .I tried but did not get how to fix the issues .It will be really helpful if you can look into this issues .
Two cases where I am missing out the right condition -
- The overlapping rules says if there is any core drug or drugs from previous regimen continues after start of current regimen and ends after start of current and the core drugs or drug starts anytime again anytime after applying 21 days and 60 days ccriteria then the overlapping rule is applied .If core drug or core drugs from previous lot continues after start of current lot but it is not started again in 21 or 60 days then the overlapping rule will not be applicable.But currenly in our code it is considerin only the core drug continues after start of current lot but it is not considering whther it is start again within 60 days or not
- In case of a lot contains core and non core drug the enddate should the end date of latest use of core drug .But in our code it is not considering it.
These two patient id is having the above two issues .I triedto explain in details why I am not getting the correct output in the below cases.
For patient id 245689 - A Cred drug Dabrafenib starts on 14 apr 2015 and we need to check what are the oter drugs available within 21 days of 14 apr 2015.We do not have any other drug in 21days.So lot 1 will have Dabrafenib.The intial end date would 14may 2015.But as a new core drug other than lot 1 starts before the lot 1 so lot 1 ends on 1 day prior to start of Trametinib Dimethyl Sulfoxide whiich is 5may2015.Lot 2 starts on 6 th may.Now we need to check what are the are therewhich starts in 21 days of 6 th may.We get did not any drug in 21 days so intial lot 2 will have Trametinib Dimethyl Sulfoxide and intial end date will be 4june2015..Now we need to check 60 dya from 4june2015.We get drug dabrafenib starts on 2jun2015 .Itis now a overlapping situation becasue from lot 1 dabranib actually ends date is 14 may205 which is after the start date of lot 2 and it again starts on anytime in lot 2 so dabrafenib will be included in lot 2 .end date would be the end date of latest use drug which is 24 jul 2015.But as a new core drug Nivolumab starts before 24jul2015.The end date would be the 1 day prior to the start dae of Nivolumab.So lot 2 ends on 13jul2015.Lot 3 starts on 14jul2015 with a lot intiative drug Nivolumab .Now we need tocheck drug within21 days .but we did not find any drug and so on.Althoug drug Dabrafenib and Trametinib Dimethyl Sulfoxide continues after start of lot 3 but these drugs did not start again any time within 21 or 60 days.So it willl not be considered as overlapping so i will not be included in lot 3 .So lot 3ends on 14 jul2015.But currentl in our code it is considering as overlaping case which should not be.
For patient id 4589759 - A non core drug Carboplatin starts on 1 oct 2013.Now weneed to check what are the drugs starts with 21 dyas of start of Carboplatin.So we get Paclitaxel along with Carboplatin starts within 21 days of start of lot initiative drug Carboplatin.So lot 1 will have carboplatin and paclitaxel.Maximum end date of these drug is 21 oct 2013.Now we need to check within 60 days after 21oct2013 any drug from lot 1 are there or not .If there then enddate will update with new date .But while checking 60 days we found a core drug Temazolomide starts on 25 oct 2013.So as per the rule of new lot start,There should be a minimum 60 days gap of no drug use or any new core drug found .So lot 1 ends on 21oct2013.Lot 2 satrts on 25oct13 witha lot inititive drug Temozolomide.Now again we need to identify drugs within 21 days of 25 oct2013.We found drug Paclitaxel and carboplatin within 21 days .So lot 2 will have Temozolomide,Paclitaxel,Carboplatin.As it is a combination of core and non core drug in the lot,the end date will be the end date of the core drug Temozolomide from where we need to check 60 days criteria.As there is no core drug from previous regimen found within days ,the lot ends on 21 nov 2013.In case of current lot is (core plus non core lot) or (core only lot ) ,then we need to check if any core drugs available from initial 21 days ,then only end date will update otherwise it will be the same while checking 60 days criteria after intial 21 days criteria.For non coreonly lot,we need tocheck if there is any non core drug from initial 21 days while checking 60 dyas criteriaa then end datewill update othewise it woill be th same .So in this case temozolomde core drug did not find within 60 days again .so end date of lot will be 21 nov 2013.But in our code currently it is updating the end date to 27 jun 2014 as non core drug is found within applying 60 days criteria which should be ignored as per the rule.So lot 3 begins on 23 jun 2014 and ends on 27 jun 2014 .We are getting the wrong date at lot 3 becoz it is taking the maximum end date of non care here it should end date of core crugs in case of only core or core plus non core regimen.
Data I have -
data have; length patient_id $15. drug_name $50. ; input patient_id (drug_name drug_type) ($) (start end) (: date11.); format start end date9.; cards; 245689 Dabrafenib Core 14-Apr-15 14-May-15 245689 Trametinib_Dimethyl_Sulfoxide Core 6-May-15 4-Jun-15 245689 Dabrafenib Core 2-Jun-15 1-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 2-Jun-15 1-Jul-15 245689 Dabrafenib Core 25-Jun-15 24-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-15 24-Jul-15 245689 Nivolumab Core 14-Jul-15 14-Jul-15 4589759 Carboplatin Non_core 1-Oct-13 1-Oct-13 4589759 Paclitaxel Non_core 1-Oct-13 1-Oct-13 4589759 Carboplatin Non_core 7-Oct-13 7-Oct-13 4589759 Paclitaxel Non_core 7-Oct-13 7-Oct-13 4589759 Carboplatin Non_core 14-Oct-13 14-Oct-13 4589759 Paclitaxel Non_core 14-Oct-13 14-Oct-13 4589759 Carboplatin Non_core 21-Oct-13 21-Oct-13 4589759 Paclitaxel Non_core 21-Oct-13 21-Oct-13 4589759 Temozolomide Core 25-Oct-13 21-Nov-13 4589759 Paclitaxel Non_core 30-Oct-13 30-Oct-13 4589759 Paclitaxel Non_core 5-Nov-13 5-Nov-13 4589759 Carboplatin Non_core 13-Nov-13 13-Nov-13 4589759 Paclitaxel Non_core 13-Nov-13 13-Nov-13 4589759 Carboplatin Non_core 19-Nov-13 19-Nov-13 4589759 Paclitaxel Non_core 19-Nov-13 19-Nov-13 4589759 Carboplatin Non_core 27-Nov-13 27-Nov-13 4589759 Paclitaxel Non_core 27-Nov-13 27-Nov-13 4589759 Carboplatin Non_core 4-Dec-13 4-Dec-13 4589759 Paclitaxel Non_core 4-Dec-13 4-Dec-13 4589759 Carboplatin Non_core 11-Dec-13 11-Dec-13 4589759 Paclitaxel Non_core 11-Dec-13 11-Dec-13 4589759 Paclitaxel Non_core 27-Dec-13 27-Dec-13 4589759 Paclitaxel Non_core 23-Jun-14 27-Jun-14 4589759 Dabrafenib Core 4-Aug-14 2-Sep-14 4589759 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14 4589759 Trametinib_Dimethyl_Sulfoxide Core 17-Sep-14 16-Oct-14 4589759 Dabrafenib Core 26-Sep-14 25-Oct-14 4589759 Dabrafenib Core 15-Oct-14 15-Oct-14 4589759 Dabrafenib Core 21-Nov-14 20-Dec-14 4589759 Trametinib_Dimethyl_Sulfoxide Core 21-Nov-14 20-Dec-14 ;
Data I want -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 05MAY2015 1
245689 Dabrafenib+ Trametinib Dimethyl Sulfoxide 06MAY2015 13JUL2015 2
245689 Nivolumab 14JUL2015 14JUL2015 3
4589759 Carboplatin+Paclitaxel 01OCT2013 21OCT2013 1
4589759 Carboplatin+Paclitaxel+Temozolomide 25OCT2013 21NOV2013 2
4589759 Paclitaxel 23JUN2014 27JUN2014 3
4589759 Dabrafenib+Trametinib Dimethyl Sulfoxide 04AUG2014 20DEC2014 4
Data I am currently getting -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 05MAY2015 1
245689 Trametinib Dimethyl Sulfoxide+Dabrafenib 06MAY2015 13JUL2015 2
245689 Nivolumab+Dabrafenib+Trametinib Dimethyl Sulfoxide 14JUL2015 24JUL2015 3
4589759 Carboplatin+Paclitaxel 01OCT2013 21OCT2013 1
4589759 Temozolomide+Paclitaxel+Carboplatin 25OCT2013 27DEC2013 2
4589759 Paclitaxel 23JUN2014 27JUN2014 3
4589759 Dabrafenib+Trametinib Dimethyl Sulfoxide 04AUG2014 20DEC2014 4
Thanks in advance.
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Based on one of your responses I had removed the core requirement to increase dates. It's included, again, below.
The analysis appears to correctly deal with patient 4589759.
I don't recall ever seeing data for patient 245689, thus can't respond:
/* last revised 21JUL2017 1:02 pm EDT, but 14JUL2017 was better*/
data have;
length patient_id $15. drug_name $50. ;
infile cards delimiter='09'x;
input patient_id (drug_name drug_type) ($) (start end) (: date11.);
format start end date9.;
/* 14526897 Interferon_Alfa_2b Non_core 3-Sep-14 30-Sep-14 */
cards;
14526897 Interferon_Alfa_2b Non_core 11-Aug-14 11-Aug-14
14526897 Interferon_Alfa_2b Non_core 12-Aug-14 12-Aug-14
14526897 Interferon_Alfa_2b Non_core 13-Aug-14 13-Aug-14
14526897 Interferon_Alfa_2b Non_core 14-Aug-14 14-Aug-14
14526897 Interferon_Alfa_2b Non_core 15-Aug-14 15-Aug-14
14526897 Interferon_Alfa_2b Non_core 18-Aug-14 18-Aug-14
14526897 Interferon_Alfa_2b Non_core 19-Aug-14 19-Aug-14
14526897 Interferon_Alfa_2b Non_core 20-Aug-14 20-Aug-14
14526897 Interferon_Alfa_2b Non_core 21-Aug-14 21-Aug-14
14526897 Interferon_Alfa_2b Non_core 22-Aug-14 22-Aug-14
14526897 Interferon_Alfa_2b Non_core 25-Aug-14 25-Aug-14
14526897 Interferon_Alfa_2b Non_core 26-Aug-14 26-Aug-14
14526897 Interferon_Alfa_2b Non_core 27-Aug-14 27-Aug-14
14526897 Interferon_Alfa_2b Non_core 28-Aug-14 28-Aug-14
14526897 Interferon_Alfa_2b Non_core 2-Sep-14 2-Sep-14
14526897 Interferon_Alfa_2b Non_core 3-Sep-14 3-Sep-14
14526897 Interferon_Alfa_2b Non_core 4-Sep-14 4-Sep-14
14526897 Interferon_Alfa_2b Non_core 5-Sep-14 5-Sep-14
14526897 Interferon_Alfa_2b Non_core 8-Sep-14 8-Sep-14
14526897 Interferon_Alfa_2b Non_core 9-Sep-14 9-Sep-14
14526897 Interferon_Alfa_2b Non_core 13-Nov-14 10-Dec-14
14526897 Interferon_Alfa_2b Non_core 23-Dec-14 19-Jan-15
14526897 Interferon_Alfa_2b Non_core 9-Jan-15 5-Feb-15
14526897 Interferon_Alfa_2b Non_core 27-Feb-15 26-Mar-15
14526897 Interferon_Alfa_2b Non_core 17-Jun-15 14-Jul-15
897452634 Cisplatin Non_core 19-Jan-16 19-Jan-16
897452634 Dacarbazine Non_core 19-Jan-16 19-Jan-16
897452634 Ipilimumab Core 19-Jan-16 19-Jan-16
897452634 Vinblastine Non_core 19-Jan-16 19-Jan-16
897452634 Cisplatin Non_core 20-Jan-16 20-Jan-16
897452634 Vinblastine Non_core 20-Jan-16 20-Jan-16
897452634 Cisplatin Non_core 21-Jan-16 21-Jan-16
897452634 Vinblastine Non_core 21-Jan-16 21-Jan-16
897452634 Vinblastine Non_core 22-Jan-16 22-Jan-16
897452634 Cisplatin Non_core 9-Feb-16 9-Feb-16
897452634 Dacarbazine Non_core 9-Feb-16 9-Feb-16
897452634 Ipilimumab Core 9-Feb-16 9-Feb-16
897452634 Vinblastine Non_core 9-Feb-16 9-Feb-16
897452634 Cisplatin Non_core 10-Feb-16 10-Feb-16
897452634 Vinblastine Non_core 10-Feb-16 10-Feb-16
897452634 Cisplatin Non_core 11-Feb-16 11-Feb-16
897452634 Vinblastine Non_core 11-Feb-16 11-Feb-16
897452634 Vinblastine Non_core 12-Feb-16 12-Feb-16
897452634 Cisplatin Non_core 1-Mar-16 1-Mar-16
897452634 Dacarbazine Non_core 1-Mar-16 1-Mar-16
897452634 Ipilimumab Core 1-Mar-16 1-Mar-16
897452634 Vinblastine Non_core 1-Mar-16 1-Mar-16
897452634 Cisplatin Non_core 2-Mar-16 2-Mar-16
897452634 Vinblastine Non_core 2-Mar-16 2-Mar-16
897452634 Cisplatin Non_core 3-Mar-16 3-Mar-16
897452634 Vinblastine Non_core 3-Mar-16 3-Mar-16
897452634 Cisplatin Non_core 22-Mar-16 22-Mar-16
897452634 Dacarbazine Non_core 22-Mar-16 22-Mar-16
897452634 Ipilimumab Core 22-Mar-16 22-Mar-16
897452634 Vinblastine Non_core 22-Mar-16 22-Mar-16
897452634 Cisplatin Non_core 23-Mar-16 23-Mar-16
897452634 Vinblastine Non_core 23-Mar-16 23-Mar-16
897452634 Cisplatin Non_core 24-Mar-16 24-Mar-16
897452634 Vinblastine Non_core 24-Mar-16 24-Mar-16
587956 Ipilimumab Core 31-May-13 22-Aug-13
587956 Ipilimumab Core 3-Jun-13 3-Jun-13
587956 Dacarbazine Non_core 4-Jun-13 4-Jun-13
587956 Ipilimumab Core 4-Jun-13 4-Jun-13
587956 Ipilimumab Core 14-Jun-13 14-Jun-13
587956 Dacarbazine Non_core 1-Jul-13 1-Jul-13
587956 Ipilimumab Core 1-Jul-13 1-Jul-13
587956 Ipilimumab Core 3-Jul-13 3-Jul-13
587956 Dacarbazine Non_core 30-Jul-13 30-Jul-13
587956 Ipilimumab Core 30-Jul-13 30-Jul-13
587956 Dacarbazine Non_core 27-Aug-13 27-Aug-13
587956 Ipilimumab Core 27-Aug-13 27-Aug-13
587956 Ipilimumab Core 14-Oct-13 14-Oct-13
587956 Dacarbazine Non_core 15-Oct-13 15-Oct-13
9874526 Vemurafenib Core 9-May-13 7-Jun-13
9874526 Vemurafenib Core 11-Jun-13 10-Jul-13
9874526 Vemurafenib Core 13-Jun-13 13-Jun-13
9874526 Vemurafenib Core 11-Jul-13 11-Jul-13
9874526 Vemurafenib Core 13-Jul-13 11-Aug-13
9874526 Vemurafenib Core 13-Aug-13 13-Aug-13
9874526 Dabrafenib Core 19-Aug-13 17-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Aug-13 17-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Sep-13 10-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-13 17-Oct-13
9874526 Dabrafenib Core 23-Sep-13 22-Oct-13
9874526 Dabrafenib Core 8-Oct-13 8-Oct-13
9874526 Dabrafenib Core 21-Oct-13 19-Nov-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 21-Oct-13 19-Nov-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Nov-13 6-Nov-13
9874526 Dabrafenib Core 18-Nov-13 17-Dec-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Nov-13 17-Dec-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 5-Dec-13 5-Dec-13
9874526 Dabrafenib Core 23-Dec-13 21-Jan-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Dec-13 21-Jan-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Jan-14 2-Jan-14
9874526 Dabrafenib Core 20-Jan-14 18-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Jan-14 18-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Feb-14 12-Mar-14
9874526 Dabrafenib Core 18-Feb-14 19-Mar-14
9874526 Dabrafenib Core 25-Feb-14 25-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 1-Apr-14 30-Apr-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-May-14 6-May-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 7-May-14 5-Jun-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Jun-14 3-Jun-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Jun-14 5-Jul-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 8-Jul-14 6-Aug-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 17-Jul-14 17-Jul-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 7-Aug-14 5-Sep-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Aug-14 20-Aug-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Sep-14 2-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-14 18-Sep-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Oct-14 31-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Oct-14 16-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 4-Nov-14 3-Dec-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 12-Nov-14 12-Nov-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 15-Dec-14 13-Jan-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Dec-14 16-Dec-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 13-Jan-15 11-Feb-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Feb-15 10-Feb-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Feb-15 20-Mar-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Mar-15 19-Mar-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 14-Apr-15 13-May-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Apr-15 23-Apr-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 14-May-15 12-Jun-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Jun-15 10-Jul-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Jun-15 30-Jun-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 28-Jul-15 28-Jul-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 29-Jul-15 27-Aug-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-15 26-Aug-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Sep-15 1-Oct-15
9874526 Vemurafenib Core 2-Sep-15 1-Oct-15
9874526 Vemurafenib Core 24-Sep-15 24-Sep-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Sep-15 29-Oct-15
9874526 Vemurafenib Core 23-Oct-15 21-Nov-15
9874526 Cobimetinib Core 4-Dec-15 9-Jan-16
9874526 Cobimetinib Core 23-Dec-15 23-Dec-15
9874526 Cobimetinib Core 4-Jan-16 9-Feb-16
9874526 Ipilimumab Core 3-Feb-16 3-Feb-16
9874526 Nivolumab Core 3-Feb-16 3-Feb-16
874512399 Dabrafenib Core 25-Apr-14 24-May-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14
874512399 Dabrafenib Core 2-Jun-14 1-Jul-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14
874512399 Dabrafenib Core 5-Aug-14 3-Sep-14
874512399 Dabrafenib Core 16-Sep-14 15-Oct-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15
874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15
874512399 Bevacizumab Non_core 1-May-15 1-May-15
874512399 Bevacizumab Non_core 18-May-15 18-May-15
874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15
874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15
874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15
874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15
874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15
874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15
874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15
874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15
874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15
874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15
874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15
874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15
874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15
874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16
874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16
874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16
874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16
874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16
874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16
74521369845 Cisplatin Non_core 29-Jul-14 29-Jul-14
74521369845 Dacarbazine Non_core 29-Jul-14 29-Jul-14
74521369845 Vinblastine Non_core 29-Jul-14 29-Jul-14
74521369845 Cisplatin Non_core 30-Jul-14 30-Jul-14
74521369845 Vinblastine Non_core 30-Jul-14 30-Jul-14
74521369845 Cisplatin Non_core 31-Jul-14 31-Jul-14
74521369845 Vinblastine Non_core 31-Jul-14 31-Jul-14
74521369845 Cisplatin Non_core 26-Aug-14 26-Aug-14
74521369845 Dacarbazine Non_core 26-Aug-14 26-Aug-14
74521369845 Ipilimumab Core 26-Aug-14 26-Aug-14
74521369845 Vinblastine Non_core 26-Aug-14 26-Aug-14
74521369845 Cisplatin Non_core 27-Aug-14 27-Aug-14
74521369845 Vinblastine Non_core 27-Aug-14 27-Aug-14
74521369845 Cisplatin Non_core 28-Aug-14 28-Aug-14
74521369845 Vinblastine Non_core 28-Aug-14 28-Aug-14
74521369845 Cisplatin Non_core 16-Sep-14 16-Sep-14
74521369845 Dacarbazine Non_core 16-Sep-14 16-Sep-14
74521369845 Ipilimumab Core 16-Sep-14 16-Sep-14
74521369845 Vinblastine Non_core 16-Sep-14 16-Sep-14
74521369845 Cisplatin Non_core 17-Sep-14 17-Sep-14
74521369845 Vinblastine Non_core 17-Sep-14 17-Sep-14
74521369845 Cisplatin Non_core 18-Sep-14 18-Sep-14
74521369845 Vinblastine Non_core 18-Sep-14 18-Sep-14
74521369845 Vinblastine Non_core 19-Sep-14 19-Sep-14
74521369845 Cisplatin Non_core 7-Oct-14 7-Oct-14
74521369845 Dacarbazine Non_core 7-Oct-14 7-Oct-14
74521369845 Ipilimumab Core 7-Oct-14 7-Oct-14
74521369845 Vinblastine Non_core 7-Oct-14 7-Oct-14
74521369845 Cisplatin Non_core 8-Oct-14 8-Oct-14
74521369845 Vinblastine Non_core 8-Oct-14 8-Oct-14
74521369845 Cisplatin Non_core 9-Oct-14 9-Oct-14
74521369845 Vinblastine Non_core 9-Oct-14 9-Oct-14
74521369845 Vinblastine Non_core 10-Oct-14 10-Oct-14
74521369845 Cisplatin Non_core 28-Oct-14 28-Oct-14
74521369845 Dacarbazine Non_core 28-Oct-14 28-Oct-14
74521369845 Vinblastine Non_core 28-Oct-14 28-Oct-14
74521369845 Cisplatin Non_core 29-Oct-14 29-Oct-14
74521369845 Vinblastine Non_core 29-Oct-14 29-Oct-14
74521369845 Cisplatin Non_core 30-Oct-14 30-Oct-14
74521369845 Vinblastine Non_core 30-Oct-14 30-Oct-14
74521369845 Cisplatin Non_core 2-Dec-14 2-Dec-14
74521369845 Dacarbazine Non_core 2-Dec-14 2-Dec-14
74521369845 Vinblastine Non_core 2-Dec-14 2-Dec-14
74521369845 Cisplatin Non_core 3-Dec-14 3-Dec-14
74521369845 Vinblastine Non_core 3-Dec-14 3-Dec-14
74521369845 Cisplatin Non_core 4-Dec-14 4-Dec-14
74521369845 Vinblastine Non_core 4-Dec-14 4-Dec-14
4526789 Interleukin-2 Core 26-Oct-15 31-Oct-15
4526789 Interleukin-2 Core 27-Oct-15 27-Oct-15
4526789 Interleukin-2 Core 28-Oct-15 28-Oct-15
4526789 Interleukin-2 Core 29-Oct-15 29-Oct-15
4526789 Interleukin-2 Core 30-Oct-15 30-Oct-15
4526789 Interleukin-2 Core 31-Oct-15 31-Oct-15
4526789 Interferon_Alfa_2b Non_core 2-Nov-15 29-Nov-15
4526789 Interferon_Alfa_2b Non_core 16-Nov-15 20-Nov-15
4526789 Interferon_Alfa_2b Non_core 17-Nov-15 17-Nov-15
4526789 Interferon_Alfa_2b Non_core 18-Nov-15 18-Nov-15
4526789 Interferon_Alfa_2b Non_core 19-Nov-15 19-Nov-15
4526789 Interferon_Alfa_2b Non_core 20-Nov-15 20-Nov-15
4526789 Interferon_Alfa_2b Non_core 7-Dec-15 3-Jan-16
4526789 Interleukin-2 Core 7-Dec-15 11-Dec-15
4526789 Interleukin-2 Core 8-Dec-15 8-Dec-15
4526789 Interleukin-2 Core 9-Dec-15 9-Dec-15
4526789 Interleukin-2 Core 10-Dec-15 10-Dec-15
4526789 Interleukin-2 Core 11-Dec-15 11-Dec-15
4526789 Pembrolizumab Core 30-Mar-16 30-Mar-16
4526789 Pembrolizumab Core 20-Apr-16 20-Apr-16
4526789 Pembrolizumab Core 11-May-16 11-May-16
4526789 Pembrolizumab Core 18-May-16 18-May-16
4526789 Pembrolizumab Core 8-Jun-16 8-Jun-16
4526789 Pembrolizumab Core 29-Jun-16 29-Jun-16
78954526 Dabrafenib Core 25-Apr-14 24-May-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Apr-14 24-May-14
78954526 Dabrafenib Core 30-Apr-14 29-May-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 30-Apr-14 29-May-14
78954526 Dabrafenib Core 29-May-14 27-Jun-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 29-May-14 27-Jun-14
78954526 Dabrafenib Core 25-Jun-14 24-Jul-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-14 24-Jul-14
78954526 Dabrafenib Core 18-Aug-14 16-Sep-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 18-Aug-14 16-Sep-14
78954526 Dabrafenib Core 15-Sep-14 14-Oct-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 15-Sep-14 14-Oct-14
78954526 Ipilimumab Core 9-Oct-14 9-Oct-14
8745120369 Dabrafenib Core 18-Aug-14 16-Sep-14
8745120369 Dabrafenib Core 20-Aug-14 18-Sep-14
8745120369 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-14 24-Sep-14
8745120369 Trametinib_Dimethyl_Sulfoxide Core 23-Sep-14 21-Dec-14
8745120369 Dabrafenib Core 17-Oct-14 14-Jan-15
8745120369 Ipilimumab Core 22-Dec-14 22-Dec-14
4589759 Carboplatin Non_core 1-Oct-13 1-Oct-13
4589759 Paclitaxel Non_core 1-Oct-13 1-Oct-13
4589759 Carboplatin Non_core 7-Oct-13 7-Oct-13
4589759 Paclitaxel Non_core 7-Oct-13 7-Oct-13
4589759 Carboplatin Non_core 14-Oct-13 14-Oct-13
4589759 Paclitaxel Non_core 14-Oct-13 14-Oct-13
4589759 Carboplatin Non_core 21-Oct-13 21-Oct-13
4589759 Paclitaxel Non_core 21-Oct-13 21-Oct-13
4589759 Temozolomide Core 25-Oct-13 21-Nov-13
4589759 Paclitaxel Non_core 30-Oct-13 30-Oct-13
4589759 Paclitaxel Non_core 5-Nov-13 5-Nov-13
4589759 Carboplatin Non_core 13-Nov-13 13-Nov-13
4589759 Paclitaxel Non_core 13-Nov-13 13-Nov-13
4589759 Carboplatin Non_core 19-Nov-13 19-Nov-13
4589759 Paclitaxel Non_core 19-Nov-13 19-Nov-13
4589759 Carboplatin Non_core 27-Nov-13 27-Nov-13
4589759 Paclitaxel Non_core 27-Nov-13 27-Nov-13
4589759 Carboplatin Non_core 4-Dec-13 4-Dec-13
4589759 Paclitaxel Non_core 4-Dec-13 4-Dec-13
4589759 Carboplatin Non_core 11-Dec-13 11-Dec-13
4589759 Paclitaxel Non_core 11-Dec-13 11-Dec-13
4589759 Paclitaxel Non_core 27-Dec-13 27-Dec-13
4589759 Paclitaxel Non_core 23-Jun-14 27-Jun-14
4589759 Dabrafenib Core 4-Aug-14 2-Sep-14
4589759 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14
4589759 Trametinib_Dimethyl_Sulfoxide Core 17-Sep-14 16-Oct-14
4589759 Dabrafenib Core 26-Sep-14 25-Oct-14
4589759 Dabrafenib Core 15-Oct-14 15-Oct-14
4589759 Dabrafenib Core 21-Nov-14 20-Dec-14
4589759 Trametinib_Dimethyl_Sulfoxide Core 21-Nov-14 20-Dec-14
;
data want
(keep=patient_id drug start_date end_date lot)
;
set have;
by patient_id notsorted;
format start_date end_date date9.;
/* look ahead at next record */
set have ( firstobs = 2 keep = start drug_type drug_name
rename = (start = next_start drug_type=next_type drug_name=next_drug) )
have ( obs = 1 drop = _all_ );
next_start = ifn(last.patient_id, (.), next_start );
next_type = ifc(last.patient_id, (.), next_type );
next_drug = ifc(last.patient_id, (.), next_drug );
/* set length of drug to be wide enough to fix all drugs */
length drug $1000.;
length hold_drug $1000.;
array adrugs(100) $ 30 adrug1-adrug100;
array adates(100) adate1-adate100;
array hold_drugs(100) $ 30 hold_drug1-hold_drug100;
array hold_dates(100) hold_date1-hold_date100;
format adate1-adate20 date9.;
retain start_date end_date drug days adrug: adate: hold_drug: hold_date:;
/* initialize variables for first record within a given lot */
if first.patient_id or counter eq 0 then do;
if first.patient_id then do;
lot=0;
call missing (of adrugs(*));
call missing (of adates(*));
call missing (of hold_drugs(*));
call missing (of hold_dates(*));
dcounter=0;
end;
start_date=start;
end_date=end;
counter=1;
drug='';
hold_drug='';
if drug_type eq 'Core' then do;
drug=drug_name;
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
if adrugs(i) ne strip(drug_name) then do;
drug=catx('+',drug,adrugs(i));
end_date=max(end_date,adates(i));
end;
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
end;
end;
else do;
call missing (of hold_drugs(*));
call missing (of hold_dates(*));
hold_drug=drug_name;
dcounter+1;
hold_drugs(dcounter)=drug_name;
hold_dates(dcounter)=end;
end;
if next_start gt start_date+21 or missing(next_start) then do;
days=60;
if missing(drug) then do;
drug=hold_drug;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
if strip(drug_name) ne adrugs(i) then drug=catx('+',drug,adrugs(i));
end_date=max(end_date,adates(i));
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
if (not missing(hold_drugs(i))) and hold_dates(i) ge start_date then do;
if strip(drug_name) ne hold_drugs(i) then rug=catx('+',drug,hold_drugs(i));
end_date=max(end_date,hold_dates(i));
end;
else do;
call missing(hold_drugs(i));
call missing(hold_dates(i));
end;
end;
call missing(of hold_drugs(*));
call missing(of hold_dates(*));
call missing(hold_drug);
end;
end;
else days=21;
end;
/* if not first record in lot and still within 21 day period check to see if drug in drug list */
else if days eq 21 then do;
if drug_type eq 'Core' then do;
if not findw(drug,strip(drug_name)) then do;
drug=catx('+',drug,drug_name);
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
end;
do i=1 to dim(adrugs);
if drug_name eq adrugs(i) and adates(i) lt start_date then do;
adates(i)=end;
end;
end;
counter+1;
end_date=max(end_date,end);
end;
else if missing(drug) then do;
if not findw(hold_drug,strip(drug_name)) then do;
hold_drug=catx('+',hold_drug,drug_name);
dcounter+1;
hold_drugs(dcounter)=drug_name;
hold_dates(dcounter)=end;
end;
do i=1 to dim(adrugs);
if drug_name eq hold_drugs(i) and hold_dates(i) lt /*start_date*/ end then do;
hold_dates(i)=end;
end;
end;
end_date=max(end_date,end);
counter+1;
end;
/* add Non_core if lot already has at least one core */
else do;
if not findw(drug,strip(drug_name)) then do;
drug=catx('+',drug,drug_name);
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
end;
counter+1;
end;
if next_start gt start_date+21 or missing(next_start) then do;
days=60;
if missing(drug) then do;
drug=hold_drug;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
/* drug=catx('+',drug,adrugs(i)); */
end_date=max(end_date,adates(i));
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
if (not missing(hold_drugs(i))) and hold_dates(i) ge start_date then do;
/* drug=catx('+',drug,hold_drugs(i)); */
end_date=max(end_date,hold_dates(i));
end;
else do;
call missing(hold_drugs(i));
call missing(hold_dates(i));
end;
end;
call missing(of hold_drugs(*));
call missing(of hold_dates(*));
call missing(hold_drug);
end;
end;
end;
/* within 60 day check */
else do;
days=60;
/* if start le end_date+60 and findw(drug,strip(drug_name)) /* and drug_type eq 'Core'* / then do; */
if start le end_date+60 and findw(drug,strip(drug_name)) and drug_type eq 'Core' then do;
counter+1;
end_date=max(end,end_date);
do i=1 to dim(adrugs);
if adrugs(i) eq strip(drug_name) then do;
adates(i)=max(adates(i),end);
end;
end;
end;
end;
*output;
/* check to see if last.patient_id or next record indicates new lot */
if last.patient_id or
(counter gt 0 and
days eq 60 and
(next_start gt end_date+60 or
((not findw(drug,strip(next_drug))) and
next_type eq 'Core')))
then do;
if not missing(next_start) and next_start le end_date then end_date=next_start-1;
lot+1;
output;
counter=0;
end;
run;
Art, CEO, AnalystFinder.com
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Thanks for your reply. I try to understand the changes you made.It works fine for the patient id 4589759 but other ids are not matching .The rule for this analysis are below .The code you posed on 14 th July works 99% correctly only in some cases it is not giving the desired out .I have highlighted those in the red below.
- LOT1 commences at the start of first core/non-core drug starting from index date. LOT1 comprises all the core/non-core drugs initiated within 21 days of the start of LOT. Three types of regimens may be created:
- Core drugs only
- Non-core drugs only
- Core drugs + Non-core drugs
In case of Core only and Core + Non-core LOTs, a date of last use is identified by considering the latest date of last use of any of the core drugs initiated in the 21 days period. In case of Non-core only LOT, a date of last use is identified by considering the latest date of last use of any of the non-core drugs present in LOT1.
Currently it is taking only core drugs in initial 21 days which should not be the case any drug indentified irrespective of core or noncore it will be included in the lot but end date would be maximum date of latest use core drug.
- If LOT1 comprises Core drugs only or Core + Non-core drugs,
- If any of the core drugs from LOT1 is identified in a period – from end date of most recent core drug to 60 days post date of latest use of a core drug - update the date of latest use accordingly. Again, core drugs are to be identified until 60 days post updated date of last use, and so on. This step is to be repeated until either no core drugs are identified in the given period or a core drug other than the core drugs present in LOT1 is identified.
- If no core drug is identified from start date of most recent core drug to 60 days post date of latest use of a core drug, LOT1 ends at date of latest use.
- If a core drug other than the core drugs present in LOT1 is identified from start date of most recent core drug to 60 days post or 21 days period of date of latest use of a core drug, and,
- one or more core drugs from LOT1 overlap with the newly identified core drug which is not present in LOT1, then
- LOT1 ends one day prior to the beginning of newly identified core drug.
- LOT2 begins at the start of newly identified core drug. If any of the overlapping core drugs from LOT1 is further identified any time during LOT2, that drug is included in LOT2.
Currently overlapping happens if any core drug from previous lot continues after start of current lot .but we need to check if the core drug continues after start of new lot and it is being start again then this rule should be applied.
- none of the core drugs from LOT1 overlaps with the new core drug, end LOT1 at latest use of core drugs. LOT2 begins at the start of newly identified core drug.
- Non-core drugs identified during or after initial 21 days period will not affect duration of LOT1.
Currently if a lot comprises core plus non core drugs it is taking the maximum end irrespective of core or non core .But the end date should be the latest use of core drugs in this case.
- If LOT1 comprises non-core drugs only,
- If any of the non-core drugs from LOT1 is identified in a period – from end date of most recent non-core drug to 60 days post date of latest use of a non-core drug - update the date of latest use accordingly. Again, non-core drugs from LOT1 are to be identified until 60 days post updated date of last use, and so on. This step is to be repeated until either no non-core drugs from LOT1 are identified in that period or a core drug is identified.
- If no non-core drug from LOT1 is identified from start date of most recent non-core drug to 60 days post date of latest use of a non-core drug, the regimen ends at date of latest use.
- If a core drug is identified from start date of most recent non-core drug to 60 days post date of latest use of a non-core drug, and,
- one or more non-core drugs from LOT1 overlap with the newly identified core drug, then
- LOT1 ends one day prior to beginning of the newly identified core drug.
- LOT2 begins at the start of newly identified core drug.
- none of the non-core drugs from LOT1 overlaps with the newly identified core drug, end LOT1 at latest use of non-core drugs in LOT1. LOT2 begins at the start of newly identified core drug.
- After the end of an LOT, next LOT can begin,
- at start of earliest core drug post end of LOT.
- at start of earliest non-core drug after 60 days post end of LOT given that no core drug precedes it post end of previous LOT.
- The regimens, start dates and end dates of further LOTs are to be determined in a similar manner.
Thanks in advance.Please let me know in case you have any concerns.
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There was a typo in all of the previous versions that could have effected some of the output.
As such, the following is th 14Jul2017 code with the typo corrected.
Check it with what you expect/need to get as a result and let me/us know about specific discrepancies:
/* last revised 22JUL2017 5:10 pm EDT */
data have;
length patient_id $15. drug_name $50. ;
infile cards delimiter='09'x;
input patient_id (drug_name drug_type) ($) (start end) (: date11.);
format start end date9.;
cards;
14526897 Interferon_Alfa_2b Non_core 11-Aug-14 11-Aug-14
14526897 Interferon_Alfa_2b Non_core 12-Aug-14 12-Aug-14
14526897 Interferon_Alfa_2b Non_core 13-Aug-14 13-Aug-14
14526897 Interferon_Alfa_2b Non_core 14-Aug-14 14-Aug-14
14526897 Interferon_Alfa_2b Non_core 15-Aug-14 15-Aug-14
14526897 Interferon_Alfa_2b Non_core 18-Aug-14 18-Aug-14
14526897 Interferon_Alfa_2b Non_core 19-Aug-14 19-Aug-14
14526897 Interferon_Alfa_2b Non_core 20-Aug-14 20-Aug-14
14526897 Interferon_Alfa_2b Non_core 21-Aug-14 21-Aug-14
14526897 Interferon_Alfa_2b Non_core 22-Aug-14 22-Aug-14
14526897 Interferon_Alfa_2b Non_core 25-Aug-14 25-Aug-14
14526897 Interferon_Alfa_2b Non_core 26-Aug-14 26-Aug-14
14526897 Interferon_Alfa_2b Non_core 27-Aug-14 27-Aug-14
14526897 Interferon_Alfa_2b Non_core 28-Aug-14 28-Aug-14
14526897 Interferon_Alfa_2b Non_core 2-Sep-14 2-Sep-14
14526897 Interferon_Alfa_2b Non_core 3-Sep-14 3-Sep-14
14526897 Interferon_Alfa_2b Non_core 3-Sep-14 30-Sep-14
14526897 Interferon_Alfa_2b Non_core 4-Sep-14 4-Sep-14
14526897 Interferon_Alfa_2b Non_core 5-Sep-14 5-Sep-14
14526897 Interferon_Alfa_2b Non_core 8-Sep-14 8-Sep-14
14526897 Interferon_Alfa_2b Non_core 9-Sep-14 9-Sep-14
14526897 Interferon_Alfa_2b Non_core 13-Nov-14 10-Dec-14
14526897 Interferon_Alfa_2b Non_core 23-Dec-14 19-Jan-15
14526897 Interferon_Alfa_2b Non_core 9-Jan-15 5-Feb-15
14526897 Interferon_Alfa_2b Non_core 27-Feb-15 26-Mar-15
14526897 Interferon_Alfa_2b Non_core 17-Jun-15 14-Jul-15
897452634 Cisplatin Non_core 19-Jan-16 19-Jan-16
897452634 Dacarbazine Non_core 19-Jan-16 19-Jan-16
897452634 Ipilimumab Core 19-Jan-16 19-Jan-16
897452634 Vinblastine Non_core 19-Jan-16 19-Jan-16
897452634 Cisplatin Non_core 20-Jan-16 20-Jan-16
897452634 Vinblastine Non_core 20-Jan-16 20-Jan-16
897452634 Cisplatin Non_core 21-Jan-16 21-Jan-16
897452634 Vinblastine Non_core 21-Jan-16 21-Jan-16
897452634 Vinblastine Non_core 22-Jan-16 22-Jan-16
897452634 Cisplatin Non_core 9-Feb-16 9-Feb-16
897452634 Dacarbazine Non_core 9-Feb-16 9-Feb-16
897452634 Ipilimumab Core 9-Feb-16 9-Feb-16
897452634 Vinblastine Non_core 9-Feb-16 9-Feb-16
897452634 Cisplatin Non_core 10-Feb-16 10-Feb-16
897452634 Vinblastine Non_core 10-Feb-16 10-Feb-16
897452634 Cisplatin Non_core 11-Feb-16 11-Feb-16
897452634 Vinblastine Non_core 11-Feb-16 11-Feb-16
897452634 Vinblastine Non_core 12-Feb-16 12-Feb-16
897452634 Cisplatin Non_core 1-Mar-16 1-Mar-16
897452634 Dacarbazine Non_core 1-Mar-16 1-Mar-16
897452634 Ipilimumab Core 1-Mar-16 1-Mar-16
897452634 Vinblastine Non_core 1-Mar-16 1-Mar-16
897452634 Cisplatin Non_core 2-Mar-16 2-Mar-16
897452634 Vinblastine Non_core 2-Mar-16 2-Mar-16
897452634 Cisplatin Non_core 3-Mar-16 3-Mar-16
897452634 Vinblastine Non_core 3-Mar-16 3-Mar-16
897452634 Cisplatin Non_core 22-Mar-16 22-Mar-16
897452634 Dacarbazine Non_core 22-Mar-16 22-Mar-16
897452634 Ipilimumab Core 22-Mar-16 22-Mar-16
897452634 Vinblastine Non_core 22-Mar-16 22-Mar-16
897452634 Cisplatin Non_core 23-Mar-16 23-Mar-16
897452634 Vinblastine Non_core 23-Mar-16 23-Mar-16
897452634 Cisplatin Non_core 24-Mar-16 24-Mar-16
897452634 Vinblastine Non_core 24-Mar-16 24-Mar-16
587956 Ipilimumab Core 31-May-13 22-Aug-13
587956 Ipilimumab Core 3-Jun-13 3-Jun-13
587956 Dacarbazine Non_core 4-Jun-13 4-Jun-13
587956 Ipilimumab Core 4-Jun-13 4-Jun-13
587956 Ipilimumab Core 14-Jun-13 14-Jun-13
587956 Dacarbazine Non_core 1-Jul-13 1-Jul-13
587956 Ipilimumab Core 1-Jul-13 1-Jul-13
587956 Ipilimumab Core 3-Jul-13 3-Jul-13
587956 Dacarbazine Non_core 30-Jul-13 30-Jul-13
587956 Ipilimumab Core 30-Jul-13 30-Jul-13
587956 Dacarbazine Non_core 27-Aug-13 27-Aug-13
587956 Ipilimumab Core 27-Aug-13 27-Aug-13
587956 Ipilimumab Core 14-Oct-13 14-Oct-13
587956 Dacarbazine Non_core 15-Oct-13 15-Oct-13
9874526 Vemurafenib Core 9-May-13 7-Jun-13
9874526 Vemurafenib Core 11-Jun-13 10-Jul-13
9874526 Vemurafenib Core 13-Jun-13 13-Jun-13
9874526 Vemurafenib Core 11-Jul-13 11-Jul-13
9874526 Vemurafenib Core 13-Jul-13 11-Aug-13
9874526 Vemurafenib Core 13-Aug-13 13-Aug-13
9874526 Dabrafenib Core 19-Aug-13 17-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Aug-13 17-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Sep-13 10-Sep-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-13 17-Oct-13
9874526 Dabrafenib Core 23-Sep-13 22-Oct-13
9874526 Dabrafenib Core 8-Oct-13 8-Oct-13
9874526 Dabrafenib Core 21-Oct-13 19-Nov-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 21-Oct-13 19-Nov-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Nov-13 6-Nov-13
9874526 Dabrafenib Core 18-Nov-13 17-Dec-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Nov-13 17-Dec-13
9874526 Trametinib_Dimethyl_Sulfoxide Core 5-Dec-13 5-Dec-13
9874526 Dabrafenib Core 23-Dec-13 21-Jan-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Dec-13 21-Jan-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Jan-14 2-Jan-14
9874526 Dabrafenib Core 20-Jan-14 18-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Jan-14 18-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Feb-14 12-Mar-14
9874526 Dabrafenib Core 18-Feb-14 19-Mar-14
9874526 Dabrafenib Core 25-Feb-14 25-Feb-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 1-Apr-14 30-Apr-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-May-14 6-May-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 7-May-14 5-Jun-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Jun-14 3-Jun-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 6-Jun-14 5-Jul-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 8-Jul-14 6-Aug-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 17-Jul-14 17-Jul-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 7-Aug-14 5-Sep-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 20-Aug-14 20-Aug-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 3-Sep-14 2-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 18-Sep-14 18-Sep-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Oct-14 31-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Oct-14 16-Oct-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 4-Nov-14 3-Dec-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 12-Nov-14 12-Nov-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 15-Dec-14 13-Jan-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 16-Dec-14 16-Dec-14
9874526 Trametinib_Dimethyl_Sulfoxide Core 13-Jan-15 11-Feb-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 10-Feb-15 10-Feb-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Feb-15 20-Mar-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 19-Mar-15 19-Mar-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 14-Apr-15 13-May-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 23-Apr-15 23-Apr-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 14-May-15 12-Jun-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 11-Jun-15 10-Jul-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Jun-15 30-Jun-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 28-Jul-15 28-Jul-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 29-Jul-15 27-Aug-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-15 26-Aug-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 2-Sep-15 1-Oct-15
9874526 Vemurafenib Core 2-Sep-15 1-Oct-15
9874526 Vemurafenib Core 24-Sep-15 24-Sep-15
9874526 Trametinib_Dimethyl_Sulfoxide Core 30-Sep-15 29-Oct-15
9874526 Vemurafenib Core 23-Oct-15 21-Nov-15
9874526 Cobimetinib Core 4-Dec-15 9-Jan-16
9874526 Cobimetinib Core 23-Dec-15 23-Dec-15
9874526 Cobimetinib Core 4-Jan-16 9-Feb-16
9874526 Ipilimumab Core 3-Feb-16 3-Feb-16
9874526 Nivolumab Core 3-Feb-16 3-Feb-16
874512399 Dabrafenib Core 25-Apr-14 24-May-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14
874512399 Dabrafenib Core 2-Jun-14 1-Jul-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14
874512399 Dabrafenib Core 5-Aug-14 3-Sep-14
874512399 Dabrafenib Core 16-Sep-14 15-Oct-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14
874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15
874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15
874512399 Bevacizumab Non_core 1-May-15 1-May-15
874512399 Bevacizumab Non_core 18-May-15 18-May-15
874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15
874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15
874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15
874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15
874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15
874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15
874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15
874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15
874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15
874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15
874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15
874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15
874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15
874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16
874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16
874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16
874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16
874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16
874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16
74521369845 Cisplatin Non_core 29-Jul-14 29-Jul-14
74521369845 Dacarbazine Non_core 29-Jul-14 29-Jul-14
74521369845 Vinblastine Non_core 29-Jul-14 29-Jul-14
74521369845 Cisplatin Non_core 30-Jul-14 30-Jul-14
74521369845 Vinblastine Non_core 30-Jul-14 30-Jul-14
74521369845 Cisplatin Non_core 31-Jul-14 31-Jul-14
74521369845 Vinblastine Non_core 31-Jul-14 31-Jul-14
74521369845 Cisplatin Non_core 26-Aug-14 26-Aug-14
74521369845 Dacarbazine Non_core 26-Aug-14 26-Aug-14
74521369845 Ipilimumab Core 26-Aug-14 26-Aug-14
74521369845 Vinblastine Non_core 26-Aug-14 26-Aug-14
74521369845 Cisplatin Non_core 27-Aug-14 27-Aug-14
74521369845 Vinblastine Non_core 27-Aug-14 27-Aug-14
74521369845 Cisplatin Non_core 28-Aug-14 28-Aug-14
74521369845 Vinblastine Non_core 28-Aug-14 28-Aug-14
74521369845 Cisplatin Non_core 16-Sep-14 16-Sep-14
74521369845 Dacarbazine Non_core 16-Sep-14 16-Sep-14
74521369845 Ipilimumab Core 16-Sep-14 16-Sep-14
74521369845 Vinblastine Non_core 16-Sep-14 16-Sep-14
74521369845 Cisplatin Non_core 17-Sep-14 17-Sep-14
74521369845 Vinblastine Non_core 17-Sep-14 17-Sep-14
74521369845 Cisplatin Non_core 18-Sep-14 18-Sep-14
74521369845 Vinblastine Non_core 18-Sep-14 18-Sep-14
74521369845 Vinblastine Non_core 19-Sep-14 19-Sep-14
74521369845 Cisplatin Non_core 7-Oct-14 7-Oct-14
74521369845 Dacarbazine Non_core 7-Oct-14 7-Oct-14
74521369845 Ipilimumab Core 7-Oct-14 7-Oct-14
74521369845 Vinblastine Non_core 7-Oct-14 7-Oct-14
74521369845 Cisplatin Non_core 8-Oct-14 8-Oct-14
74521369845 Vinblastine Non_core 8-Oct-14 8-Oct-14
74521369845 Cisplatin Non_core 9-Oct-14 9-Oct-14
74521369845 Vinblastine Non_core 9-Oct-14 9-Oct-14
74521369845 Vinblastine Non_core 10-Oct-14 10-Oct-14
74521369845 Cisplatin Non_core 28-Oct-14 28-Oct-14
74521369845 Dacarbazine Non_core 28-Oct-14 28-Oct-14
74521369845 Vinblastine Non_core 28-Oct-14 28-Oct-14
74521369845 Cisplatin Non_core 29-Oct-14 29-Oct-14
74521369845 Vinblastine Non_core 29-Oct-14 29-Oct-14
74521369845 Cisplatin Non_core 30-Oct-14 30-Oct-14
74521369845 Vinblastine Non_core 30-Oct-14 30-Oct-14
74521369845 Cisplatin Non_core 2-Dec-14 2-Dec-14
74521369845 Dacarbazine Non_core 2-Dec-14 2-Dec-14
74521369845 Vinblastine Non_core 2-Dec-14 2-Dec-14
74521369845 Cisplatin Non_core 3-Dec-14 3-Dec-14
74521369845 Vinblastine Non_core 3-Dec-14 3-Dec-14
74521369845 Cisplatin Non_core 4-Dec-14 4-Dec-14
74521369845 Vinblastine Non_core 4-Dec-14 4-Dec-14
4526789 Interleukin-2 Core 26-Oct-15 31-Oct-15
4526789 Interleukin-2 Core 27-Oct-15 27-Oct-15
4526789 Interleukin-2 Core 28-Oct-15 28-Oct-15
4526789 Interleukin-2 Core 29-Oct-15 29-Oct-15
4526789 Interleukin-2 Core 30-Oct-15 30-Oct-15
4526789 Interleukin-2 Core 31-Oct-15 31-Oct-15
4526789 Interferon_Alfa_2b Non_core 2-Nov-15 29-Nov-15
4526789 Interferon_Alfa_2b Non_core 16-Nov-15 20-Nov-15
4526789 Interferon_Alfa_2b Non_core 17-Nov-15 17-Nov-15
4526789 Interferon_Alfa_2b Non_core 18-Nov-15 18-Nov-15
4526789 Interferon_Alfa_2b Non_core 19-Nov-15 19-Nov-15
4526789 Interferon_Alfa_2b Non_core 20-Nov-15 20-Nov-15
4526789 Interferon_Alfa_2b Non_core 7-Dec-15 3-Jan-16
4526789 Interleukin-2 Core 7-Dec-15 11-Dec-15
4526789 Interleukin-2 Core 8-Dec-15 8-Dec-15
4526789 Interleukin-2 Core 9-Dec-15 9-Dec-15
4526789 Interleukin-2 Core 10-Dec-15 10-Dec-15
4526789 Interleukin-2 Core 11-Dec-15 11-Dec-15
4526789 Pembrolizumab Core 30-Mar-16 30-Mar-16
4526789 Pembrolizumab Core 20-Apr-16 20-Apr-16
4526789 Pembrolizumab Core 11-May-16 11-May-16
4526789 Pembrolizumab Core 18-May-16 18-May-16
4526789 Pembrolizumab Core 8-Jun-16 8-Jun-16
4526789 Pembrolizumab Core 29-Jun-16 29-Jun-16
78954526 Dabrafenib Core 25-Apr-14 24-May-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Apr-14 24-May-14
78954526 Dabrafenib Core 30-Apr-14 29-May-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 30-Apr-14 29-May-14
78954526 Dabrafenib Core 29-May-14 27-Jun-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 29-May-14 27-Jun-14
78954526 Dabrafenib Core 25-Jun-14 24-Jul-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-14 24-Jul-14
78954526 Dabrafenib Core 18-Aug-14 16-Sep-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 18-Aug-14 16-Sep-14
78954526 Dabrafenib Core 15-Sep-14 14-Oct-14
78954526 Trametinib_Dimethyl_Sulfoxide Core 15-Sep-14 14-Oct-14
78954526 Ipilimumab Core 9-Oct-14 9-Oct-14
8745120369 Dabrafenib Core 18-Aug-14 16-Sep-14
8745120369 Dabrafenib Core 20-Aug-14 18-Sep-14
8745120369 Trametinib_Dimethyl_Sulfoxide Core 26-Aug-14 24-Sep-14
8745120369 Trametinib_Dimethyl_Sulfoxide Core 23-Sep-14 21-Dec-14
8745120369 Dabrafenib Core 17-Oct-14 14-Jan-15
8745120369 Ipilimumab Core 22-Dec-14 22-Dec-14
;
data want
(keep=patient_id drug start_date end_date lot)
;
set have;
by patient_id notsorted;
format start_date end_date date9.;
/* look ahead at next record */
set have ( firstobs = 2 keep = start drug_type drug_name
rename = (start = next_start drug_type=next_type drug_name=next_drug) )
have ( obs = 1 drop = _all_ );
next_start = ifn(last.patient_id, (.), next_start );
next_type = ifc(last.patient_id, (.), next_type );
next_drug = ifc(last.patient_id, (.), next_drug );
/* set length of drug to be wide enough to fix all drugs */
length drug $1000.;
length hold_drug $1000.;
array adrugs(100) $ 30 adrug1-adrug100;
array adates(100) adate1-adate100;
array hold_drugs(100) $ 30 hold_drug1-hold_drug100;
array hold_dates(100) hold_date1-hold_date100;
format adate1-adate20 date9.;
retain start_date end_date drug days adrug: adate: hold_drug: hold_date:;
/* initialize variables for first record within a given lot */
if first.patient_id or counter eq 0 then do;
if first.patient_id then do;
lot=0;
call missing (of adrugs(*));
call missing (of adates(*));
call missing (of hold_drugs(*));
call missing (of hold_dates(*));
dcounter=0;
end;
start_date=start;
end_date=end;
counter=1;
drug='';
hold_drug='';
if drug_type eq 'Core' then do;
drug=drug_name;
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
if adrugs(i) ne strip(drug_name) then do;
drug=catx('+',drug,adrugs(i));
end_date=max(end_date,adates(i));
end;
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
end;
end;
else do;
call missing (of hold_drugs(*));
call missing (of hold_dates(*));
hold_drug=drug_name;
dcounter+1;
hold_drugs(dcounter)=drug_name;
hold_dates(dcounter)=end;
end;
if next_start gt start_date+21 or missing(next_start) then do;
days=60;
if missing(drug) then do;
drug=hold_drug;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
if strip(drug_name) ne adrugs(i) then drug=catx('+',drug,adrugs(i));
end_date=max(end_date,adates(i));
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
if (not missing(hold_drugs(i))) and hold_dates(i) ge start_date then do;
if strip(drug_name) ne hold_drugs(i) then drug=catx('+',drug,hold_drugs(i));
end_date=max(end_date,hold_dates(i));
end;
else do;
call missing(hold_drugs(i));
call missing(hold_dates(i));
end;
end;
call missing(of hold_drugs(*));
call missing(of hold_dates(*));
call missing(hold_drug);
end;
end;
else days=21;
end;
/* if not first record in lot and still within 21 day period check to see if drug in drug list */
else if days eq 21 then do;
if drug_type eq 'Core' then do;
if not findw(drug,strip(drug_name)) then do;
drug=catx('+',drug,drug_name);
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
end;
do i=1 to dim(adrugs);
if drug_name eq adrugs(i) and adates(i) lt start_date then do;
adates(i)=end;
end;
end;
counter+1;
end_date=max(end_date,end);
end;
else if missing(drug) then do;
if not findw(hold_drug,strip(drug_name)) then do;
hold_drug=catx('+',hold_drug,drug_name);
dcounter+1;
hold_drugs(dcounter)=drug_name;
hold_dates(dcounter)=end;
end;
do i=1 to dim(adrugs);
if drug_name eq hold_drugs(i) and hold_dates(i) lt /*start_date*/ end then do;
hold_dates(i)=end;
end;
end;
end_date=max(end_date,end);
counter+1;
end;
/* add Non_core if lot already has at least one core */
else do;
if not findw(drug,strip(drug_name)) then do;
drug=catx('+',drug,drug_name);
dcounter+1;
adrugs(dcounter)=drug_name;
adates(dcounter)=end;
end;
counter+1;
end;
if next_start gt start_date+21 or missing(next_start) then do;
days=60;
if missing(drug) then do;
drug=hold_drug;
do i=1 to dim(adrugs);
if (not missing(adrugs(i))) and adates(i) ge start_date then do;
/* drug=catx('+',drug,adrugs(i)); */
end_date=max(end_date,adates(i));
end;
else do;
call missing(adrugs(i));
call missing(adates(i));
end;
if (not missing(hold_drugs(i))) and hold_dates(i) ge start_date then do;
/* drug=catx('+',drug,hold_drugs(i)); */
end_date=max(end_date,hold_dates(i));
end;
else do;
call missing(hold_drugs(i));
call missing(hold_dates(i));
end;
end;
call missing(of hold_drugs(*));
call missing(of hold_dates(*));
call missing(hold_drug);
end;
end;
end;
/* within 60 day check */
else do;
days=60;
if start le end_date+60 and findw(drug,strip(drug_name)) /*and drug_type eq 'Core'*/ then do;
counter+1;
end_date=max(end,end_date);
do i=1 to dim(adrugs);
if adrugs(i) eq strip(drug_name) then do;
adates(i)=max(adates(i),end);
end;
end;
end;
end;
*output;
/* check to see if last.patient_id or next record indicates new lot */
if last.patient_id or
(counter gt 0 and
days eq 60 and
(next_start gt end_date+60 or
((not findw(drug,strip(next_drug))) and
next_type eq 'Core')))
then do;
if not missing(next_start) and next_start le end_date then end_date=next_start-1;
lot+1;
output;
counter=0;
end;
run;
Art, CEO, AnalystFinder.com
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Sir. For these two patient ids am not getting he desired output. I tried all possible ways to modify the codes to get the results. But i did not succeed .I have explained the logic in details to get the desired output .I will be really grateful if you kindly look into this issues .
For patient id 245689 - A core drug Dabrafenib starts on 14 apr 2015 and we need to check what are the other drugs available within 21 days of 14 apr 2015.We do not have any other drug in 21days.So lot 1 will have Dabrafenib.The initial end date would be 14may 2015.But as a new core drug other than lot 1 starts before 14may 2015 , lot 1 ends on 1 day prior to start of Trametinib Dimethyl Sulfoxide whiich is 5may2015.Lot 2 starts on 6 th may. Now we need to check what are other drug or drugs which starts in 21 days of 6 th may.We get did not any drug in 21 days so initial lot 2 will have Trametinib Dimethyl Sulfoxide and intial end date will be 4june2015..Now we need to check 60 days from 4june2015.We get drug dabrafenib starts on 2jun2015 .It is now a overlapping situation becasue from lot 1 dabranib actually continues till 14 may2015 which is after the start date of lot 2 and it again starts on anytime in lot 2 so dabrafenib will be included in lot 2 .end date would be the end date of latest use drug which is 24 jul 2015.But as a new core drug Nivolumab starts before 14jul2015.The end date would be the 1 day prior to the start dae of Nivolumab.So lot 2 ends on 13jul2015.Lot 3 starts on 14jul2015 with a lot intiative drug Nivolumab .Now we need to check drug within21 days .but we did not find any drug and so on.Althoug drug Dabrafenib and Trametinib Dimethyl Sulfoxide continues after start of lot 3 but these drugs did not start again any time within 21 or 60 days.So it will not be considered as overlapping so i will not be included in lot 3 .So lot 3ends on 14 jul2015.But currently in our code it is considering as overlapping case which should not be.
Note - If a core drug from previous lot continues on or after start of current lot and again it will start any time while checking 21 days or 60 days then the core drug or drugs from previous lot will include in current lot and end will update accordingly of the latest .E.G - Let’s assume a situation where Lot 1 ends on 1 apr 2016 .Lot 1 contains core drug C1 and non core drug N2.Both the drugs continues till 10 apr 2016.As a new core drug C3 starts on 5 apr 2015,lot 1 ends on 1 day prior to this ..Lot 1 ends on 4apr 2015..Lot2 starts on 5 th apr 2015 while checking 21 days and 60 days criteria .We did not get any other drug. So lot will have only C2.Although from lot1 core drug C1 continues till 10 apr 2015 which is a date after start of lot 2,we will not not include in C1 the lot 3 as C1 did not start again any time while checking 21 days or 60 days criteria.If we had found another start of C1 anytime while checking 21 days or 60 days criteria, it would have been included in the lot .
For patient id 874512399 - Core drug Dabrafenib starts on 25 april and within 21 days Trametinib Dimethyl Sulfoxide starts and latest use of the core drug is 28may2014. now applying 60 days criteria we get lot 1 ends on 21jan 2015.As per the rule of new lot start ethier there shold be no use of drug within 60 days or there is any new core drug starts within 60 days.Here from end date of lot1 is 21jan2015 with a blank period of more than 60 days.So lot2 starts on 16apr2015 .after applying 21 days criteris we get Bevacizumab starts within 21 days and after applying 60 days criteria there is no core drug found .so lot 2 ends on 16apr2015.To start of lot 3 ,there should be gap of blank 60 days with no drug use or a new core drug other than previous lot should be there .So applying this rule we get Bevacizumab starts on 16june2015 and applying 21 days from 16jun2015 we did not find any core or non core drug in intial 21 days.As only non core drug found in initial 21 days lot3 is non core only lot .So while checking 60 days criteria ,we need to chec kany drug from initial 21 days start within 60 days or not .If starts the end date of this lot will increase according to the maximum end date .And then again need to check 60 days from updated end date until there is a blank period of 60 days with no drug use or a new core drug starts.Any new non core drug find in 60 days checking we can ignore the new core drug .As stated earlier a new core drug Pembrolizumab while checking 60 days criteria ,the lot 3 ends on 1 day prior to start of this newly identified core drug .We get lot 3 ends on 7apr2016. Lot4 starts on 8apr2016.Although Bevacizumab continue till 8apr2015.We will not include in lot 4 as it is a non core drug .
Note - If a core drug from previous lot continues on or after start of current lot and again it will start any time while checking 21 days or 60 days then the core drug or drugs from previous lot will include in current lot and end will update accordingly of the latest .E.G - Let’s assume a situation where Lot 1 ends on 1 apr 2016 .Lot 1 contains core drug C1 and non core drug N2.Both the drugs continues till 10 apr 2016.As a new core drug C3 starts on 5 apr 2015,lot 1 ends on 1 day prior to this ..Lot 1 ends on 4apr 2015..Lot2 starts on 5 th apr 2015 while checking 21 days and 60 days criteria .We did not get any other drug.So lot will have only C2.Although from lot1 core drug C1 continues till 10 apr 2015 which is a date after start of lot 2,we will not not include in C1 the lot 3 as C1 did not start again any time while checking 21 days or 60 days criteria. If we had found another start of C1 anytimewhile checking 21 days or 60 days criteria, it would have been included in the lot .
Data I have -
data have; length patient_id $15. drug_name $50. ; input patient_id (drug_name drug_type) ($) (start end) (: date11.); format start end date9.; cards; 245689 Dabrafenib Core 14-Apr-15 14-May-15 245689 Trametinib_Dimethyl_Sulfoxide Core 6-May-15 4-Jun-15 245689 Dabrafenib Core 2-Jun-15 1-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 2-Jun-15 1-Jul-15 245689 Dabrafenib Core 25-Jun-15 24-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-15 24-Jul-15 245689 Nivolumab Core 14-Jul-15 14-Jul-15 874512399 Dabrafenib Core 25-Apr-14 24-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14 874512399 Dabrafenib Core 2-Jun-14 1-Jul-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14 874512399 Dabrafenib Core 5-Aug-14 3-Sep-14 874512399 Dabrafenib Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15 874512399 Bevacizumab Non_core 1-May-15 1-May-15 874512399 Bevacizumab Non_core 18-May-15 18-May-15 874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15 874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15 874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15 874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15 874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15 874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15 874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15 874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15 874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15 874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15 874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15 874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15 874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15 874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16 874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16 874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16 874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16 874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16 874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16 ;
Data I want -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 05MAY2015 1
245689 Dabrafenib+ Trametinib Dimethyl Sulfoxide 06MAY2015 13JUL2015 2
245689 Nivolumab 14JUL2015 14JUL2015 3
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25APR2014 21JAN2015 1
874512399 Bevacizumab+Trametinib Dimethyl Sulfoxide 16APR2015 16APR2015 2
874512399 Bevacizumab 16JUN2015 07APR2016 3
874512399 Pembrolizumab 08APR2016 08APR2016 4
Output I am currently getting -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 5-May-15 1
245689 Trametinib_Dimethyl_Sulfoxide+Dabrafenib 6-May-15 13-Jul-15 2
245689 Nivolumab+Dabrafenib+Trametinib_Dimethyl_Sulfoxide 14-Jul-15 24-Jul-15 3
874512399 Dabrafenib+Trametinib_Dimethyl_Sulfoxide 25-Apr-14 21-Jan-15 1
874512399 Trametinib_Dimethyl_Sulfoxide+Bevacizumab 16-Apr-15 16-Apr-15 2
874512399 Bevacizumab 16-Jun-15 16-Jun-15 3
874512399 Bevacizumab 25-Aug-15 25-Aug-15 4
874512399 Bevacizumab 27-Oct-15 13-Nov-15 5
874512399 Bevacizumab 15-Jan-16 5-Feb-16 6
874512399 Pembrolizumab 8-Apr-16 8-Apr-16 7
Thanks in advance .It will be really helpful if you can see the problem once.
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Let's start by looking at the first patient (245689). If you ran that with the code I posted just before your post you would have received:
245689 14APR2015 05MAY2015 Dabrafenib 1 245689 06MAY2015 13JUL2015 Trametinib_Dimethyl_Sulfoxide+Dabrafenib 2 245689 14JUL2015 24JUL2015 Nivolumab+Dabrafenib+Trametinib_Dimethyl_Sulfoxide 3
You described a lot, but the output agrees with all except lot3 where the code carries over two drugs and their end dates while you say it shouldn't. Like I've said, I don't understand your overlapping rule(s). In previous posts, you've said that a core drug should remain active until it's end date. However, you are now saying (as I understand it) that there isn't any such applicable rule. A previous core drug is only considered if it is again prescribed during the initial 21 day period.
If that is correct, then there is no need to consider overlaps as the drug will simply be added during the initial 21 day period when it reappears.
You didn't run the data through the code I most recently posted as, otherwise, you would have received the following results for the other patient:
874512399 25APR2014 21JAN2015 Dabrafenib+Trametinib_Dimethyl_Sulfoxide 1 874512399 16APR2015 07APR2016 Trametinib_Dimethyl_Sulfoxide+Bevacizumab 2 874512399 08APR2016 08APR2016 Pembrolizumab+Bevacizumab 3
Still different from what you say you want/need, but appears to be related to what should and shouldn't be carried over.
Art, CEO, AnalystFinder.com
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As I just explained above for those two patient id where am not getting the desired output .I have now explained discrepancies and overlapping rules in details.For patient id 874512399 i ran the code you posted yesterday where you restricted the core requirement to check my desired output and that output I posted here.Let me know if you need more information.
The discrepancies are as bellows (in bullet list)
- We are missing out something while checking the overlapping rule .
The rule says - We will not include non core drug from previous lot in current lot if it continues after start of current lot irrespective of whether it is found anytime in 21 days or 60 days .We will include core drug from previous lot in current lot only if it starts again in current lot within 21 days or 60 days .
Note - If a core drug from previous lot continues on or after start of current lot and again it will start any time while checking 21 days or 60 days then the core drug or drugs from previous lot will include in current lot and end will update accordingly of the latest .E.G - Let’s assume a situation where Lot 1 ends on 1 apr 2016 .Lot 1 contains core drug C1 and non core drug N2.Both the drugs continues till 10 apr 2016.As a new core drug C3 starts on 5 apr 2015,lot 1 ends on 1 day prior to this ..Lot 1 ends on 4apr 2015..Lot2 starts on 5 th apr 2015 while checking 21 days and 60 days criteria .We did not get any other drug.So lot will have only C2.Although from lot1 core drug C1 continues till 10 apr 2015 which is a date after start of lot 2,we will not include in C1 the lot 3 as C1 did not start again any time while checking 21 days or 60 days criteria. If we had found another start of C1 anytime while checking 21 days or 60 days criteria, it would have been included in the lot .
This is the case with id 245689 with lot 3 that is why the end date of lot 3 increases to 24 july .But this is should not be the case as none of the drugs either Dabrafenib or Trametinib Dimethyl Sulfoxide starts again anytime in lot 3 .But currently the code is checking whther any of the core drug from previous lot continues or not .But it is not checking whether it starts again or not.
- If a lot having both core and non core drug then end date of the lot will be the maximum end date of latest use core drug not the non core drug.Fot this if we find any core and non core drug in initial 21 days .we will check whether the core drug is again available in the 60 days checking or not. If not available then end will be the end date of latest use core drug in initial 21 days.If a lot having only non core drugs in intial 21 daysthen we will check whether any non core drug from preious lot is there in 60 days checking or not.If available the the end would the latest use non core drug.This is the case with id 874512399.
- If a lot having both core and non core drug in initial 21 days.We should include both core and non drug.Currently it is not inluding non core drug in the lot .This is case with patient id 54871
I have given explanation in detail for each patient id where we are missing the rules.
For patient id 245689 - A core drug Dabrafenib starts on 14 apr 2015 and we need to check what are the other drugs available within 21 days of 14 apr 2015.We do not have any other drug in 21days.So lot 1 will have Dabrafenib.The initial end date would be 14may 2015.But as a new core drug other than lot 1 starts before 14may 2015 , lot 1 ends on 1 day prior to start of Trametinib Dimethyl Sulfoxide whiich is 5may2015.Lot 2 starts on 6 th may. Now we need to check what are other drug or drugs which starts in 21 days of 6 th may.We get did not any drug in 21 days so initial lot 2 will have Trametinib Dimethyl Sulfoxide and intial end date will be 4june2015..Now we need to check 60 days from 4june2015.We get drug dabrafenib starts on 2jun2015 .It is now a overlapping situation becasue from lot 1 dabranib actually continues till 14 may2015 which is after the start date of lot 2 and it again starts on anytime in lot 2 so dabrafenib will be included in lot 2 .end date would be the end date of latest use drug which is 24 jul 2015.But as a new core drug Nivolumab starts before 14jul2015.The end date would be the 1 day prior to the start dae of Nivolumab.So lot 2 ends on 13jul2015.Lot 3 starts on 14jul2015 with a lot intiative drug Nivolumab .Now we need to check drug within21 days .but we did not find any drug and so on.Althoug drug Dabrafenib and Trametinib Dimethyl Sulfoxide continues after start of lot 3 but these drugs did not start again any time within 21 or 60 days.So it will not be considered as overlapping so i will not be included in lot 3 .So lot 3ends on 14 jul2015.But currently in our code it is considering as overlapping case which should not be.
Note - If a core drug from previous lot continues on or after start of current lot and again it will start any time while checking 21 days or 60 days then the core drug or drugs from previous lot will include in current lot and end will update accordingly of the latest .E.G - Let’s assume a situation where Lot 1 ends on 1 apr 2016 .Lot 1 contains core drug C1 and non core drug N2.Both the drugs continues till 10 apr 2016.As a new core drug C3 starts on 5 apr 2015,lot 1 ends on 1 day prior to this ..Lot 1 ends on 4apr 2015..Lot2 starts on 5 th apr 2015 while checking 21 days and 60 days criteria .We did not get any other drug. So lot will have only C2.Although from lot1 core drug C1 continues till 10 apr 2015 which is a date after start of lot 2,we will not not include in C1 the lot 3 as C1 did not start again any time while checking 21 days or 60 days criteria.If we had found another start of C1 anytime while checking 21 days or 60 days criteria, it would have been included in the lot .
For patient id 874512399 - Core drug Dabrafenib starts on 25 april and within 21 days Trametinib Dimethyl Sulfoxide starts and latest use of the core drug is 28may2014. now applying 60 days criteria we get lot 1 ends on 21jan 2015.As per the rule of new lot start ethier there shold be no use of drug within 60 days or there is any new core drug starts within 60 days.Here from end date of lot1 is 21jan2015 with a blank period of more than 60 days.So lot2 starts on 16apr2015 .after applying 21 days criteris we get Bevacizumab starts within 21 days and after applying 60 days criteria there is no core drug found .so lot 2 ends on 16apr2015.To start of lot 3 ,there should be gap of blank 60 days with no drug use or a new core drug other than previous lot should be there .So applying this rule we get Bevacizumab starts on 16june2015 and applying 21 days from 16jun2015 we did not find any core or non core drug in intial 21 days.As only non core drug found in initial 21 days lot3 is non core only lot .So while checking 60 days criteria ,we need to check any non core drug from initial 21 days starts within 60 days or not .If starts the end date of this lot will increase according to the maximum end date .And then again need to check 60 days from updated end date until there is a blank period of 60 days with no drug use or a new core drug starts.Any new non core drug find in 60 days checking we can ignore the new core drug .As stated earlier ,a new core drug Pembrolizumab found while checking 60 days criteria ,the lot 3 ends on 1 day prior to start of this newly identified core drug .We get lot 3 ends on 7apr2016. Lot4 starts on 8apr2016.Although Bevacizumab continue till 8apr2015.We will not include in lot 4 as it is a non core drug .
Note - If a core drug from previous lot continues on or after start of current lot and again it will start any time while checking 21 days or 60 days then the core drug or drugs from previous lot will include in current lot and end will update accordingly of the latest .E.G - Let’s assume a situation where Lot 1 ends on 1 apr 2016 .Lot 1 contains core drug C1 and non core drug N2.Both the drugs continues till 10 apr 2016.As a new core drug C3 starts on 5 apr 2015,lot 1 ends on 1 day prior to this ..Lot 1 ends on 4apr 2015..Lot2 starts on 5 apr 2015 while checking 21 days and 60 days criteria .We did not get any other drug.So lot will have only C2.Although from lot1 core drug C1 continues till 10 apr 2015 which is a date after start of lot 2,we will not include in C1 the lot 3 as C1 did not start again any time while checking 21 days or 60 days criteria. If we had found another start of C1 anytime while checking 21 days or 60 days criteria, it would have been included in the lot .
For patient id 54871 - A non core drug Fludarabine starts on 10apr2015 .Now we need to check what are other drug found in 21 days of 10apr2015 ,we get core drug Interlukin-2 .So lot 1 will have Fludarabine and Interlukin-2.All the other rules will remain same. But currently in our code it is not including a non core drug if it starts before core drug in 21 days period. As per the rule we need to include whatever drugs are available in initial 21 days irrespective of core or non core .If it is core and non core lot ,then core drug will get preference .
Data I have -
I have given a smaller data to understand the issues easily as the earlier data was bigger. As the problems are same I have given a smaller data.
data have; length patient_id $15. drug_name $50. ; input patient_id (drug_name drug_type) ($) (start end) (: date11.); format start end date9.; cards; 245689 Dabrafenib Core 14-Apr-15 14-May-15 245689 Trametinib_Dimethyl_Sulfoxide Core 6-May-15 4-Jun-15 245689 Dabrafenib Core 2-Jun-15 1-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 2-Jun-15 1-Jul-15 245689 Dabrafenib Core 25-Jun-15 24-Jul-15 245689 Trametinib_Dimethyl_Sulfoxide Core 25-Jun-15 24-Jul-15 245689 Nivolumab Core 14-Jul-15 14-Jul-15 874512399 Dabrafenib Core 25-Apr-14 24-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14 874512399 Dabrafenib Core 2-Jun-14 1-Jul-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14 874512399 Dabrafenib Core 5-Aug-14 3-Sep-14 874512399 Dabrafenib Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15 874512399 Bevacizumab Non_core 1-May-15 1-May-15 874512399 Bevacizumab Non_core 18-May-15 18-May-15 874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15 874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15 874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15 874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15 874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15 874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15 874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15 874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15 874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15 874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15 874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15 874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15 874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15 874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16 874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16 874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16 874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16 874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16 874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16 54871 Fludarabine Non_core 10-Apr-14 10-Apr-14 54871 Fludarabine Non_core 11-Apr-14 11-Apr-14 54871 Fludarabine Non_core 12-Apr-14 12-Apr-14 54871 Interleukin-2 Core 15-Apr-14 22-Apr-14 54871 Interleukin-2 Core 16-Apr-14 16-Apr-14 54871 Interleukin-2 Core 17-Apr-14 17-Apr-14 54871 Interleukin-2 Core 18-Apr-14 18-Apr-14 54871 Interleukin-2 Core 19-Apr-14 19-Apr-14 54871 Interleukin-2 Core 20-Apr-14 20-Apr-14 54871 Interleukin-2 Core 21-Apr-14 21-Apr-14 ;
Data I want -
Data I want -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 05MAY2015 1
245689 Dabrafenib+ Trametinib Dimethyl Sulfoxide 06MAY2015 13JUL2015 2
245689 Nivolumab 14JUL2015 14JUL2015 3
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25APR2014 21JAN2015 1
874512399 Bevacizumab+Trametinib Dimethyl Sulfoxide 16APR2015 16APR2015 2
874512399 Bevacizumab 16JUN2015 07APR2016 3
874512399 Pembrolizumab 08APR2016 08APR2016 4
54871 Fludarabine+Interleukin-2 10APR2014 22APR2014 1
Data I am currently getting from the code -
patient_id drug start_date end_date lot
245689 Dabrafenib 14-Apr-15 5-May-15 1
245689 Trametinib_Dimethyl_Sulfoxide+Dabrafenib 6-May-15 13-Jul-15 2
245689 Nivolumab+Dabrafenib+Trametinib_Dimethyl_Sulfoxide 14-Jul-15 24-Jul-15 3
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25-Apr-14 21-Jan-15 1
874512399 Trametinib Dimethyl Sulfoxide+Bevacizumab 16-Apr-15 7-Apr-16 2
874512399 Pembrolizumab+Bevacizumab 8-Apr-16 8-Apr-16 3
54871 Interleukin-2 10APR2014 22APR2014 1
Thanks in advance.Please let me know if you have any concerns.
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I'll have to leave this for someone else as I don't understand your requirements and can't spend any more time on your problem
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Sir thanks for your reply.The rules are bit complex.
As you mentioned below yesterday -
You described a lot, but the output agrees with all except lot3 where the code carries over two drugs and their end dates while you say it shouldn't. Like I've said, I don't understand your overlapping rule(s). In previous posts, you've said that a core drug should remain active until it's end date. However, you are now saying (as I understand it) that there isn't any such applicable rule. A previous core drug is only considered if it is again prescribed during the initial 21 day period.
If that is correct, then there is no need to consider overlaps as the drug will simply be added during the initial 21 day period when it reappears. --------- This is correct.I explained you wrongly the overlapping rule in my previous post.For patient id 245689 ,output is fine as it should be.
Only thing I am not getting the desired output for patient id 874512399 .It will be really helpful if you kindly look into this once.
For patient id 874512399 -
Lot 1 is fine .
But for lot 2 as it is a core plus non core lot,end date would be end of latest use of core drug.While comparing 60 days criteria we should look for only core drug as it is core plus non core lot.But in our code it is now checking the maximum end date what ever available irrespective of core or non core lot .That is why we are ending the lot on 7april2016.As per the logic we should end it on 16 april2015 which is the maximum end of used core drug of lot 2 and then we check should check for a blank gapof 60 days or a new core drug to start for begining of lot 3 .As there is a blank days of 60 days after 16april2015 till 16jun2015,lot3 begins on 16thjune with a non core Bevacizumab and checking in 21 days we did not find any other drug .As only non core drug present in lot 3 ,it is non core only lot.So while checking 60 days we need to look for non core drug fom initial 21 days.After checking we found lot 3 ends on 8 th april as new core drug starts.
We are not considering whether a lot core lot or non core only lot in our code that is why we are getting 3 lot as output.But actually it should be 4.I tried to change in the code code but did not able to do that.We just need to check whther a lot core lot or non core only lot and end date should update accordingly.If it is core onlyor core plus non core lot theenddae would maximum end date of core drug after applying 21 days and 60 days rule.If a lot is non core only then end date would be the maximun end date of non core drug in initial 21 days.
I left with only this patient id .If you please look into these to impletent this logic.I would be really really grateful.
Thanks in advance.
Output am currently getting -
874512399 25APR2014 21JAN2015 Dabrafenib+Trametinib_Dimethyl_Sulfoxide 1 874512399 16APR2015 07APR2016 Trametinib_Dimethyl_Sulfoxide+Bevacizumab 2 874512399 08APR2016 08APR2016 Pembrolizumab+Bevacizumab 3
Output i want to have -
patient_id drug start_date end_date lot
874512399 Dabrafenib+Trametinib Dimethyl Sulfoxide 25APR2014 21JAN2015 1
874512399 Bevacizumab+Trametinib Dimethyl Sulfoxide 16APR2015 16APR2015 2
874512399 Bevacizumab 16JUN2015 07APR2016 3
874512399 Pembrolizumab +Bevacizumab 08APR2016 08APR2016 4
Data I have -
data have; length patient_id $15. drug_name $50. ; input patient_id (drug_name drug_type) ($) (start end) (: date11.); format start end date9.; cards; 874512399 Dabrafenib Core 25-Apr-14 24-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 29-Apr-14 28-May-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 30-May-14 28-Jun-14 874512399 Dabrafenib Core 2-Jun-14 1-Jul-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 4-Aug-14 2-Sep-14 874512399 Dabrafenib Core 5-Aug-14 3-Sep-14 874512399 Dabrafenib Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Sep-14 15-Oct-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 11-Nov-14 11-Nov-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 1-Dec-14 1-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Dec-14 21-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 22-Dec-14 22-Dec-14 874512399 Trametinib_Dimethyl_Sulfoxide Core 21-Jan-15 21-Jan-15 874512399 Trametinib_Dimethyl_Sulfoxide Core 16-Apr-15 16-Apr-15 874512399 Bevacizumab Non_core 1-May-15 1-May-15 874512399 Bevacizumab Non_core 18-May-15 18-May-15 874512399 Bevacizumab Non_core 2-Jun-15 2-Jun-15 874512399 Bevacizumab Non_core 16-Jun-15 16-Jun-15 874512399 Bevacizumab Non_core 8-Jul-15 8-Jul-15 874512399 Bevacizumab Non_core 22-Jul-15 22-Jul-15 874512399 Bevacizumab Non_core 5-Aug-15 5-Aug-15 874512399 Bevacizumab Non_core 25-Aug-15 25-Aug-15 874512399 Bevacizumab Non_core 17-Sep-15 17-Sep-15 874512399 Bevacizumab Non_core 1-Oct-15 1-Oct-15 874512399 Bevacizumab Non_core 14-Oct-15 14-Oct-15 874512399 Bevacizumab Non_core 27-Oct-15 27-Oct-15 874512399 Bevacizumab Non_core 13-Nov-15 13-Nov-15 874512399 Bevacizumab Non_core 4-Dec-15 4-Dec-15 874512399 Bevacizumab Non_core 24-Dec-15 24-Dec-15 874512399 Bevacizumab Non_core 15-Jan-16 15-Jan-16 874512399 Bevacizumab Non_core 5-Feb-16 5-Feb-16 874512399 Bevacizumab Non_core 26-Feb-16 26-Feb-16 874512399 Bevacizumab Non_core 18-Mar-16 18-Mar-16 874512399 Bevacizumab Non_core 8-Apr-16 8-Apr-16 874512399 Pembrolizumab Core 8-Apr-16 8-Apr-16 ;
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