I want to write a SAS syntax and run an analysis to evaluate the release of drug in an in vitro system across time periods.
I intend to use the First order and HIguchi model equations to get values of release constant.
The equations are
First Order: C = Coe(-kt)
Higuchi model : Mt / M∞ = Ktn (n is a superscript).
I would be grateful for any help.
Here is the syntax i was trying to develop:
DATA RELEASE;
Input TIME IVR SPECIES$;
Cards;
0.5 25.23453368 RCT
1 42.27780807 RCT
2 57.41862589 RCT
4 66.45725747 RCT
8 73.90717437 RCT
12 76.55205776 RCT
24 80.6309246 RCT
0.5 26.7912474 GCT
1 32.34728724 GCT
2 43.19154218 GCT
4 58.16394836 GCT
8 66.98968011 GCT
12 71.2555386 GCT
24 74.88005282 GCT
;
PROC SORT DATA = WORK.RELEASE;
BY SPECIES;
RUN;
PROC PLOT DATA = WORK.RELEASE;
BY SPECIES;
RUN;
Use proc NLIN to fit your equations.
It is not clear what is the relationship between IVR, Mt and C.
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