You might have an object reference in your project - i.e. to an external file - but the external file is no more around (that would then be the "instance").
That's the same like having a shortcut in Windows but the file/program the shortcut is pointing to is no more around or moved to another path.
This error might be the result of a bug, but can probably be worked around / fixed easily. You'll need to contact tech support though for more diagnosis and appropriate advice.
Chris
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