A custom format applied to the statistic in the case of proc tabulate.
Perhaps
proc format library=work;
value myblank
0 - 9 =' '
;
run;
proc tabulate data = TITLE;
class CNS_DV
URBAN_RURAL
INDV_CLT_AGE_2018
INDV_CLT_GNDR_CD
CLT_PREF_LANG_CD;
format URBAN_RURAL $URB_RUR.
INDV_CLT_AGE_2018 AGE_GROUPS.
INDV_CLT_GNDR_CD $CLT_GENDER.
CLT_PREF_LANG_CD $LANG.;
table (CNS_DV = 'Subdivision' * URBAN_RURAL = 'Urban/Rural'),
(INDV_CLT_AGE_2018 = 'Age Groups' * INDV_CLT_GNDR_CD = '' * CLT_PREF_LANG_CD = '')
* (N=''*f=myblank.)
;
run;
Other procedures would require different syntax to apply the format.