I am trying out the following code in SAS 9.4 and SAS/STAT version 14.1   proc mixed data=test; class a b; model y= a b a*b; lsmeans a*b / diff; lsmestimate a*b 'AB11 - AB12' 1 -1 0 0 0 0 0 0 0 0; slice a*b / sliceby(a='1') diff; contrast 'AB11 - AB12' b 1 -1 a*b 1 -1 0 0 0 0 0 0 0 0; estimate 'AB11 - AB12' b 1 -1 a*b 1 -1 0 0 0 0 0 0 0 0; run;   (The above code can be found in this link - http://support.sas.com/kb/24/addl/fusion_24447_1_contrasts.sas.txt)   I am not able to figure out as to why the LSMESTIMATE and SLICE statements are not working (Displayed in red color). I checked the SAS Documentation, both LSMESTIMATE and SLICE statements are there for proc mixed. What may be wrong with this..? As soon as I change the "MIXED" keyword to "GENMOD" or "GLIMMIX", it is working.   Please help me figure it out. I need to use proc mixed since I want to perform a MMRM analysis with a step-down method of checking the LSMEANS difference between treatment groups and between each treatment group and PLacebo group. I also want to use DDFM=KR option as a correction for the Degrees of freedom. As far as I know, these things can be done with proc mixed. Please help me with the LSMESTIMATE and SLICE Statement in Proc Mixed.     Thanks   Regards,   Writwik ... View more