@Shmuel: Thank you. TIME, DOSE are important here. Several doses (>1) are given per subject and each dose is given in time. For instance, ID=2, received doses at time=0 and time=96. dose=1 and serial=. represent those dosing events. Serial samples are >= 3 consecutive samples (DOSE=0) associated with same dose (including predose samples). The samples at TIME=2 were set to SERIAL=1 as they are non-consecutive samples (<=3 consecutive samples), because at TIME=96 next dose is given. Following dose at TIME=96, there are serial samples (>=3) or <= 192 hr from the first dose (from TIME=100 to TIME=267), and hence these serial samples are coded as 2. Samples from TIME=604 to TIME=1637 are > 192 hr from first dose and hence were set to SERIAL=1. For ID=1, First dose is given at TIME=0, second dose at TIME=72 & third dose at TIME=169. Samples between TIME=1 and TIME=169 are >= 3 consecutive samples or within <=192 hr from the first dose and hence are coded SERIAL=2. DOSES given at later TIME points such as 169, 240, 337 etc.. do not have >=3 samples subsequent to them and hence are coded as SERIAL=1. In case if >=3 consecutive samples are present after TIME=169, those samples will be coded as SERIAL=3 and so on. Hope this information helps. Please let me know if you have any questions. Thank you.
... View more