Hi I know this forum is mainly for help with the SAS code itself and I have received some fantastic answers here, I would really appreciate if anyone could please help me with this. I am doing a regression analysis, looking at the effect of 2 drugs (A or B) in a population where we stratified individuals by ethnic group: Estimates for European Population proc logistic data=Studydatabase; class sex drug study; model Efficacy (event='Good')= drug age sex weight egfr; where population='European'; run; Effect OddsRatioEst LowerCL UpperCL ProbChiSq Age 1.005 0.973 1.037 0.7729 Drug A vs B 1.862 1.229 2.821 0.0033 Sex Female vs Male 1.469 0.925 2.334 0.1033 Weight 1.015 1.001 1.028 0.0346 eGFR 1.006 0.995 1.016 0.2967 ________________________________________ Estimates for Asian Population proc logistic data=Studydatabase; class sex drug study; model Efficacy (event='Good')= drug age sex weight egfr; where population='Asian'; run; Obs Effect OddsRatioEst LowerCL UpperCL ProbChiSq 1 Age 1.047 0.994 1.103 0.0839 2 Drug A vs B 0.719 0.217 2.382 0.5892 3 Sex Female vs Male 1.932 0.445 8.384 0.3795 4 Weight 0.987 0.954 1.020 0.4357 5 eGFR 1.014 0.991 1.036 0.2300 As you can notice, the influence of drug is significant in the European, but not in the Asian population. One could interpret this as the effect of the drug being modified according to the study subpopulation, and hence expect the p value for interaction to be significant, but it is not at all! proc logistic data=Studydatabase; class sex drug study; model effectnum (event='Good')= study drug age sex weight egfr population*drug; run; Interactin term P value ProbChiSq 0.1874 I know this forum is mainly for questions regarding the SAS code itself, but I would appreciate any help from all the SAS and statistics experts here Best wishes Am Any explanation please? Am I missing something
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