Hi @yongheelee1212
Something I am missing in ....
Course of Treatment is defined if the therapy given is not part of the previous course of treatment and if the drug is given at least twice in 30 days. So for instance, at the beginning, course of treatment is none. so first requirement is already satisfied but the drug has to be given at least twice in 30 days. Drug 1 from first and second observation would not be first course of treatment because it does not meet the second requirement.
So as you can see from the top picture, drug 2(10/30/2012) would be beginning of course of treatment, hence cot1. The drugs observed from 10/30/2012 to 11/30/2012 is drug 2 and drug 3, hence drugs associated with cot1 would be drug2 and drug3).
cot1 continues until new drug is observed consecutively in 30 days, which is drug4 on 3/5/2013. hence, cot2 starts on 3/5/2013.
COT1 starts with drug1 on 10/16/2012 continues with drug2 and drug3 with 30-day gaps through 2/5/2013. On 2/12/2013 drug1 comes back. Drug4 joins with drug1 on 2/19/2013.
Questions are:
[1] Hence, COT1 joining with drug4 is deemed to be a new sequence. Is this right?
[2] why do you say Cot2 starts on 3/5/2013 when Drug4 was started earlier on 2/19/2013?
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