There is no baseline in the usual sense where we have some sort of intervention. I just have 3 datapoints across time. I would like to use time as continous because they are not identical across patients. I also have a small sample, so I want to minimize the number of parameters as much as possible. Group should not be random, you are right. Based on your reference, I came up with: proc mixed data = dat; class subject group eye; model y= group/solution; random int time/ subject=eye(subject); lsmeans group/ pdiff adjust=tukey; run; But I am still getting a G matrix not positive definite error. Not sure what to do?
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