Dear all
Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax
For Example:
Obs | Subject | Ratio for AUCT | Ratio for AUC00 | Ratio for Cmax | Lund | Prescott | Outlier |
1 | 1 | 1.40988 | 1.31543 | 0.91176 | 2.73085 | 3.27961 | No |
2 | 2 | 0.95385 | 0.94783 | 0.96886 | 1.00064 | 3.27961 | No |
Best Regards
Ahmed
Dear all
Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax
For Example:
Obs | Subject | Ratio for AUCT | Ratio for AUC00 | Ratio for Cmax | Lund | Prescott | Outlier |
1 | 1 | 1.40988 | 1.31543 | 0.91176 | 2.73085 | 3.27961 | No |
2 | 2 | 0.95385 | 0.94783 | 0.96886 | 1.00064 | 3.27961 | No |
Best Regards
Ahmed
Try posting this to the Community for SAS Statistical Procedures
I am not familiar with Lund's Test. Can you post a reference? I found this discussion
http://forum.bebac.at/mix_entry.php?id=2144
Many years ago james Handsfield at the CDC developed a SAS macro for detecting outliers. If you want to see what he did, his paper is at http://www2.sas.com/proceedings/sugi23/Posters/p197.pdf
Thank you Rick
I found this code:
Proc glm outstat=Lund;
class Subject Treat Seq Period;
MODEL Log_AUCT Log_AUCinf Log_Cmax=seq subject(seq) Treat period;
lsmeans Treat/stderr; Estimate 'test-ref' Treat -1 1;
Output out=Lund P=PRED R=RESID stdr=eresid STUDENT=STDRESID;
run;
Best Regards
Ahmed
I have to use Lunds test for Oultlier detection in BE study. In some reference, I found SAS code CALCKE is used for this test. please share the script to run this test
Hello @varinderk ,
I think the CALCKE code is offered in a very voluminous PDF (45MB) from the FDA in the USA.
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/203760Orig1s000.pdf
Search for CALCKE, there's SAS macro code beyond page 400!
Kind regards,
Koen
Available on demand!
Missed SAS Innovate Las Vegas? Watch all the action for free! View the keynotes, general sessions and 22 breakouts on demand.
Learn the difference between classical and Bayesian statistical approaches and see a few PROC examples to perform Bayesian analysis in this video.
Find more tutorials on the SAS Users YouTube channel.