BookmarkSubscribeRSS Feed
ahmedazab88
Fluorite | Level 6

Dear all

Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax

For Example:

ObsSubjectRatio for AUCTRatio for AUC00Ratio for CmaxLundPrescottOutlier
111.409881.315430.911762.730853.27961No
220.953850.947830.968861.000643.27961No

Best Regards

Ahmed

6 REPLIES 6
ahmedazab88
Fluorite | Level 6

Dear all

Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax

For Example:

ObsSubjectRatio for AUCTRatio for AUC00Ratio for CmaxLundPrescottOutlier
111.409881.315430.911762.730853.27961No
220.953850.947830.968861.000643.27961No

Best Regards

Ahmed

Rick_SAS
SAS Super FREQ

Try posting this to the Community for SAS Statistical Procedures

I am not familiar with Lund's Test. Can you post a reference?  I found this discussion

http://forum.bebac.at/mix_entry.php?id=2144

Many years ago james Handsfield at the CDC developed a SAS macro for detecting outliers. If you want to see what he did, his paper is at http://www2.sas.com/proceedings/sugi23/Posters/p197.pdf

ahmedazab88
Fluorite | Level 6

Thank you Rick

ahmedazab88
Fluorite | Level 6

I found this code:

Proc glm outstat=Lund;

class Subject Treat Seq Period;

MODEL Log_AUCT Log_AUCinf Log_Cmax=seq subject(seq) Treat period;

lsmeans Treat/stderr; Estimate 'test-ref' Treat -1 1;

Output out=Lund P=PRED R=RESID stdr=eresid STUDENT=STDRESID;

run;

Best Regards

Ahmed

varinderk
Calcite | Level 5

I have to use Lunds test for Oultlier detection in BE study. In some reference, I found SAS code CALCKE is used for this test. please share the script to run this test

sbxkoenk
SAS Super FREQ

Hello @varinderk ,

I think the CALCKE code is offered in a very voluminous PDF (45MB) from the FDA in the USA.
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/203760Orig1s000.pdf

Search for CALCKE, there's SAS macro code beyond page 400!

Kind regards,

Koen

sas-innovate-white.png

Our biggest data and AI event of the year.

Don’t miss the livestream kicking off May 7. It’s free. It’s easy. And it’s the best seat in the house.

Join us virtually with our complimentary SAS Innovate Digital Pass. Watch live or on-demand in multiple languages, with translations available to help you get the most out of every session.

 

Register now!

What is Bayesian Analysis?

Learn the difference between classical and Bayesian statistical approaches and see a few PROC examples to perform Bayesian analysis in this video.

Find more tutorials on the SAS Users YouTube channel.

SAS Training: Just a Click Away

 Ready to level-up your skills? Choose your own adventure.

Browse our catalog!

Discussion stats
  • 6 replies
  • 5883 views
  • 6 likes
  • 4 in conversation