Dear all
Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax
For Example:
Obs | Subject | Ratio for AUCT | Ratio for AUC00 | Ratio for Cmax | Lund | Prescott | Outlier |
1 | 1 | 1.40988 | 1.31543 | 0.91176 | 2.73085 | 3.27961 | No |
2 | 2 | 0.95385 | 0.94783 | 0.96886 | 1.00064 | 3.27961 | No |
Best Regards
Ahmed
Dear all
Can you help me to make Lund Test for Outlier Analysis in Ratios to be used in bioequivalence studies, var AUC & Cmax
For Example:
Obs | Subject | Ratio for AUCT | Ratio for AUC00 | Ratio for Cmax | Lund | Prescott | Outlier |
1 | 1 | 1.40988 | 1.31543 | 0.91176 | 2.73085 | 3.27961 | No |
2 | 2 | 0.95385 | 0.94783 | 0.96886 | 1.00064 | 3.27961 | No |
Best Regards
Ahmed
Try posting this to the Community for SAS Statistical Procedures
I am not familiar with Lund's Test. Can you post a reference? I found this discussion
http://forum.bebac.at/mix_entry.php?id=2144
Many years ago james Handsfield at the CDC developed a SAS macro for detecting outliers. If you want to see what he did, his paper is at http://www2.sas.com/proceedings/sugi23/Posters/p197.pdf
Thank you Rick
I found this code:
Proc glm outstat=Lund;
class Subject Treat Seq Period;
MODEL Log_AUCT Log_AUCinf Log_Cmax=seq subject(seq) Treat period;
lsmeans Treat/stderr; Estimate 'test-ref' Treat -1 1;
Output out=Lund P=PRED R=RESID stdr=eresid STUDENT=STDRESID;
run;
Best Regards
Ahmed
I have to use Lunds test for Oultlier detection in BE study. In some reference, I found SAS code CALCKE is used for this test. please share the script to run this test
Hello @varinderk ,
I think the CALCKE code is offered in a very voluminous PDF (45MB) from the FDA in the USA.
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/203760Orig1s000.pdf
Search for CALCKE, there's SAS macro code beyond page 400!
Kind regards,
Koen
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