If the variables in the expressions for your calculated variables have the same name in the new dataset, then the calculated variables should be OK. For example, if you have a calculated variable "Profit" with the expression "Revenue - Expenses", then the calculated variable should be OK if the new data set has variables named "Revenue" and "Expenses." I believe this to be the case. I would verify it but my test server is down for maintenance at the moment. If the calculated variables are lost when you change data sets, you can re-create them easily by using the text mode of the expression editor. You can simply copy the expression code from one report and then paste it in the new one.
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