Hi,
My question relates to general guidance when conducting regression analysis, and I have therefore not provided example data.
I have a patient population with N=1,000.
In this population, a small number of patients (n<50) received a particular drug, which is the exposure focus of interest in my analysis.
I want to run a logistic regression to examine the effect of a patient exposed to this drug and their risk of hospital admission.
To obtain an adjusted effect estimate, I need to include 6 co-variates in my model. When I do this, I get an odds-ratio of ~2 (SE 0.8), and the CIs for the effect estimate are quite wide, no doubt partly due to the small sample.
I am aware of the "rule of 10 events per variable" when running logistic regression, but I am wondering if I am interpreting this correctly - in my above example, does this mean 10 hospital admissions per co-variate included in my model, or 10 patients exposed to the drug of interest per co-variate included in my model?
Thank you in advance for your help,
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