Hello,
i need to perform a futility analysis where the hypothesis of testing are:
The null hypothesis H0: Rc-Ra ≤ -10
The alternative hypothesis H1: Rc-Ra > -10
where Rc and Ra are the response rate of treatments C and A respectively.
At the end of the study Nc = 450, Na = 300 subjects.
where Nc and Na are the number of subjects planned to be randomised in treatments C and A respectively.
At futility analysis time, i have Nc = 215, Na = 143 subjects and Rc=0.703 and Ra=0.618
i need to calculate the conditional power at time of futility analysis.
i looked into SAS support but i am not really clear what procedure is the most appropriate and the SAS codes/options.
thanks for your help.