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12-29-2007 09:42 AM

I request help from SAS experts regarding references on applications of SAS in Cancer studies, especially Kaplan Meier Estimates,Hazard ratio and Exact Confidence Intervals.

Thanks,

Anil

Thanks,

Anil

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12-29-2007 10:41 AM

Hi:

I always find a search of support.sas.com and/or Google to be of great help when researching topics in SAS. What I generally find is that if I can't immediately find the procedure I want, either Google or SAS Support will point me in a direction. This is the search routine I followed:

One place I start is the Frequently Asked Statistics page:

http://support.sas.com/kb/30/333.html

Then if I don't find what I think I need there, I go to Google. A search of the following terms

SAS Kaplan Meier

SAS Hazard ratio

SAS Exact Confidence Intervals

on Google revealed these hits:

SAS Kaplan Meier:

http://www2.sas.com/proceedings/sugi30/156-30.pdf

http://ssc.utexas.edu/docs/sashelp/sugi/23/Stats/p226.pdf

http://www.lexjansen.com/pharmasug/2006/technicaltechniques/tt07.pdf

http://www4.stat.ncsu.edu/~dzhang2/st745/chap2.pdf

SAS Exact Confidence Interval:

http://ssc.utexas.edu/docs/sashelp/sugi/23/Stats/p249.pdf

http://www.bsos.umd.edu/econ/evans/econ321/ci_example.pdf

http://www.doh.wa.gov/Data/Guidelines/ConfIntguide.htm

SAS Hazard ratio:

http://www.ats.ucla.edu/stat/SAS/faq/survival_repeated_events.htm

http://aac.asm.org/cgi/content/full/48/8/2787

Quickly browsing a few of the above papers, indicated that the topics can all be found in a discussion of Survival Analysis. So then, I went to SAS Publishing and searched for books on Survival Analysis:

http://books.google.com/books/sas?hl=en&q=survival+analysis

...and found

SAS(R) Survival Analysis Techniques for Medical Research, 2nd edition

ISBN 1590471350

which has this description:

"If you are new to survival analysis or want to expand your capabilities in this area, you'll benefit from Alan Cantor's follow-up to Extending SAS Survival Analysis Techniques for Medical Research. This second edition presents the theory and methods of survival analysis along with excellent discussions of the SAS procedures used to implement the methods described. New features include a discussion of permutation and randomization tests; a discussion of the use of data imputation; an expanded discussion of power for Cox regression; descriptions of the new features of SAS 9, such as confidence bands for the Kaplan-Meier curve; appendixes that cover mathematical and statistical background topics needed in survival analysis; and student exercises. The new features, along with several useful macros and numerous examples, make this a suitable textbook for a course in survival analysis for biostatistics majors and majors in related fields. This book excels at presenting complex ideas in a way that enables those without a strong technical background to understand and apply the concepts and techniques."

And one of my searches led me back to the SAS/STAT manual because these 3 procedures seem to be the ones referenced in most of the papers/discussions:

Survival Analysis Procedures (SAS/STAT):

LIFEREG

LIFETEST

PHREG

cynthia

I always find a search of support.sas.com and/or Google to be of great help when researching topics in SAS. What I generally find is that if I can't immediately find the procedure I want, either Google or SAS Support will point me in a direction. This is the search routine I followed:

One place I start is the Frequently Asked Statistics page:

http://support.sas.com/kb/30/333.html

Then if I don't find what I think I need there, I go to Google. A search of the following terms

SAS Kaplan Meier

SAS Hazard ratio

SAS Exact Confidence Intervals

on Google revealed these hits:

SAS Kaplan Meier:

http://www2.sas.com/proceedings/sugi30/156-30.pdf

http://ssc.utexas.edu/docs/sashelp/sugi/23/Stats/p226.pdf

http://www.lexjansen.com/pharmasug/2006/technicaltechniques/tt07.pdf

http://www4.stat.ncsu.edu/~dzhang2/st745/chap2.pdf

SAS Exact Confidence Interval:

http://ssc.utexas.edu/docs/sashelp/sugi/23/Stats/p249.pdf

http://www.bsos.umd.edu/econ/evans/econ321/ci_example.pdf

http://www.doh.wa.gov/Data/Guidelines/ConfIntguide.htm

SAS Hazard ratio:

http://www.ats.ucla.edu/stat/SAS/faq/survival_repeated_events.htm

http://aac.asm.org/cgi/content/full/48/8/2787

Quickly browsing a few of the above papers, indicated that the topics can all be found in a discussion of Survival Analysis. So then, I went to SAS Publishing and searched for books on Survival Analysis:

http://books.google.com/books/sas?hl=en&q=survival+analysis

...and found

SAS(R) Survival Analysis Techniques for Medical Research, 2nd edition

ISBN 1590471350

which has this description:

"If you are new to survival analysis or want to expand your capabilities in this area, you'll benefit from Alan Cantor's follow-up to Extending SAS Survival Analysis Techniques for Medical Research. This second edition presents the theory and methods of survival analysis along with excellent discussions of the SAS procedures used to implement the methods described. New features include a discussion of permutation and randomization tests; a discussion of the use of data imputation; an expanded discussion of power for Cox regression; descriptions of the new features of SAS 9, such as confidence bands for the Kaplan-Meier curve; appendixes that cover mathematical and statistical background topics needed in survival analysis; and student exercises. The new features, along with several useful macros and numerous examples, make this a suitable textbook for a course in survival analysis for biostatistics majors and majors in related fields. This book excels at presenting complex ideas in a way that enables those without a strong technical background to understand and apply the concepts and techniques."

And one of my searches led me back to the SAS/STAT manual because these 3 procedures seem to be the ones referenced in most of the papers/discussions:

Survival Analysis Procedures (SAS/STAT):

LIFEREG

LIFETEST

PHREG

cynthia

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12-29-2007 08:48 PM

Anil,

You will likely find the references to the software used for a particular Cancer study analysis in the methods section of the papers in the medical literature. Just go to medline and search on the acronym for the cooperative groups (CALGB, POG, ACoSOG, etc.), or just page through any issue of the Journal of the National Cancer Institute for an idea.

I know CALGB and ACoSOG routinely use SAS for analyses. They may also use S+ or R for some.

Doc

You will likely find the references to the software used for a particular Cancer study analysis in the methods section of the papers in the medical literature. Just go to medline and search on the acronym for the cooperative groups (CALGB, POG, ACoSOG, etc.), or just page through any issue of the Journal of the National Cancer Institute for an idea.

I know CALGB and ACoSOG routinely use SAS for analyses. They may also use S+ or R for some.

Doc

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12-29-2007 11:40 PM

Thank you for your prompt reply.

Anil

Anil