PBE calculation for In vitro study of Nasal spray.

[NaineshPatel]

ofHello All,

I need your help on the In vitro PBE calculation for nasal spray.There is a guideline for PBE calculation but it is not clear to how to derive PBE calculation.Can any one suggest me or any software is there?

Guideline Ref:

1.  CDER:Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for local inhalation. April 2003

2.      CDER: Statistical Approaches to Establishing Bioequivalence Jan2001.

Please feel free to contact us for further queries and information

naineshp@glenmarkpharma.com

Regards,

Nainesh Patel

+919158659501