ED50 Calculations

Reply
Occasional Contributor
Posts: 8

ED50 Calculations

I need to calculate the ED50 for a vasoconstriction pilot bioequivalence for corticosteroids as specified in the FDA Guidance "Guidance Topical Dermatologic Corticosteroids: In Vivo Bioequivalence" 2 June 1995. Please help me learn to do this in SAS.
Thanks
SAS Super FREQ
Posts: 8,868

Re: ED50 Calculations

Hi:
Example 71.1 in the PROC PROBIT documentation specifically mentions dosages and ED50:
http://support.sas.com/documentation/cdl/en/statug/63033/HTML/default/statug_probit_sect034.htm#

cynthia
Occasional Contributor
Posts: 8

Re: ED50 Calculations

Since the response for vasoconstriction pilot studies is AUC, not the number of subjects responding to a particular dose Proc Probit can not be used.
Trusted Advisor
Posts: 2,116

Re: ED50 Calculations

This article may help, it used something called an Emax model.

Clinical Pharmacology & Therapeutics 66, 346–357 (1 October 1999) | doi:10.1053/cp.1999.v66.a101209

Try a google search for
ed50 bioequivalence dermatologic
Occasional Contributor
Posts: 8

Re: ED50 Calculations

Thanks Doc,

An Emax model is what I am looking for.

Craig
Occasional Contributor k2k
Occasional Contributor
Posts: 10

Re: ED50 Calculations

dear craigWW.

i need the same for vasoconstriction study. if u have the sas code can u share me or guide me in this.

Occasional Learner
Posts: 1

Re: ED50 Calculations

Hi All,

 

I want to calculate the ED50 and EMax using population model in SAS? Is there any built in procedure available in SAS to do this? I have read on some paper about SAS MIXLIN Macro, anyone have idea about this Macro?

  

 

 

 

Ask a Question
Discussion stats
  • 6 replies
  • 3182 views
  • 0 likes
  • 5 in conversation