04-03-2017 05:40 AM
I need help for design a noninferiorty trial with seqdesign .
The Trial is a Randomized, multicentre, double blind placebo-controlled non inferiority trial with the aim to demonstrate the effectiveness of a 50% reduced drug dose regimen to prevent event compared to complete dose
My hypothesis are :
-Non-inferiority margin =-0.04.
-20% of patients respond to the curent traitement
How I can plan this analysis with seqdesign and alpha spending function ?