Programming the statistical procedures from SAS

noninferiority trial with interim analyses usign seqdesign

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noninferiority trial with interim analyses usign seqdesign

hi everybody,

I need help for design a noninferiorty trial with seqdesign .

The Trial is a Randomized, multicentre, double blind placebo-controlled non inferiority trial with the aim to demonstrate the effectiveness of a 50% reduced drug dose regimen to prevent event compared to complete dose

My hypothesis are  :

-binaray outcome

-Non-inferiority margin =-0.04.

-Power=0.80

-20% of patients respond to the curent traitement

 

How I can plan this analysis with seqdesign and alpha spending function ?

 

thinks

Damir

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