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Ashwini_uci
Obsidian | Level 7

Hi,

I have performed proc logistic for un-stratified and age-stratified analyses, but strangle, my un-stratified Odds Ratio is way smaller than the individual stratified OR (ODDS ratio)  values. It should be close to an average of the other 2 stratified OR values.

Here are the ORs.

The red coloed value is no where close to the average of the 2 stratified ORs.

CKD Stage III/IV- Overall1.74 (1.67-1.82)
Age <652.02 (1.82 -2.25)
Age >=651.95 (1.86 - 2.03)


CKD Stage V/ESRD Overall 3.79 (3.62- 3.96)
Age <654.41 (4.04- 4.81)
Age >=653.52 (3.34- 3.70)


I checked and rechecked my coding and program but don't find anything wrong with it. I am not able to figure out why the overall OR is not close to the average of the other 2 ORs.

The program code are as below. The red colored variable is variable of interest. It has 3 levels, 0,1 and 2 and 0 is reference category, 1= CKD stage III/IV and 2- CKD stage 5. Each program gives 2 Odds ratio values for this variable; 1 compared to 0 and 2 compared to 0. Interestingly the OR values for CKD stage V look correct and the overall OR seems to be an average of the other 2 stratified ORs.

Any suggestions, advice would be greatly appreciated.

proc logistic data =

class   female  (ref= first) renalicd9_3 (ref=first) dm_all_comorbid htn_c  dyslipidemia aids alcohol ANEMDEF arth race1(ref=first)  

ZIPINC_QRTL(ref=first) hosp_location h_contrl(ref=first) hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph

lytes mets neuro obese para perivasc psych pulmcirc  tumor ulcer valve wghtloss cararrhythmia  sepsis pneumonia/param=ref;

model anyproc1_15_1=  age female los dm_all_comorbid TOTAL_DISC htn_c  dyslipidemia aids alcohol ANEMDEF arth race1  ZIPINC_QRTL hosp_location

h_contrl hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph lytes mets neuro obese para perivasc

psych pulmcirc tumor ulcer valve wghtloss cararrhythmia  sepsis pneumonia renalicd9_3;

where stemi=1;

weight discwt;

title 'Logi Reg anyproc vs renalicd9 in MI patients with RACE +income  for stemi';

run;

quit;

proc logistic data =library.Nismicathckdmiss_pcilos30_1 descending;

class  female  (ref= first) renalicd9_3 (ref=first) dm_all_comorbid htn_c  dyslipidemia aids alcohol ANEMDEF arth race1(ref=first)  

ZIPINC_QRTL(ref=first) hosp_location h_contrl(ref=first) hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph

lytes mets neuro obese para perivasc psych pulmcirc  tumor ulcer valve wghtloss cararrhythmia sepsis pneumonia/param=ref;

model anyproc1_15_1=   female los dm_all_comorbid TOTAL_DISC htn_c  dyslipidemia aids alcohol ANEMDEF arth race1  ZIPINC_QRTL hosp_location

h_contrl hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph lytes mets neuro obese para perivasc

psych pulmcirc tumor ulcer valve wghtloss cararrhythmia sepsis pneumonia renalicd9_3;

where stemi=1 and agecat3=1;

weight discwt;

title 'Logi Reg anyproc vs renalicd9 in MI patients with RACE +income  for stemi <65';

run;

quit;

proc logistic data =library.Nismicathckdmiss_pcilos30_1 descending;

class  female  (ref= first) renalicd9_3 (ref=first) dm_all_comorbid htn_c  dyslipidemia aids alcohol ANEMDEF arth race1(ref=first)  

ZIPINC_QRTL(ref=first) hosp_location h_contrl(ref=first) hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph

lytes mets neuro obese para perivasc psych pulmcirc  tumor ulcer valve wghtloss cararrhythmia sepsis pneumonia /param=ref;

model anyproc1_15_1=   female los dm_all_comorbid TOTAL_DISC htn_c  dyslipidemia aids alcohol ANEMDEF arth race1  ZIPINC_QRTL hosp_location

h_contrl hosp_teach bldloss chf chrnlung coag depress drug hypothy liver lymph lytes mets neuro obese para perivasc

psych pulmcirc tumor ulcer valve wghtloss cararrhythmia sepsis pneumonia renalicd9_3;

where stemi=1 and agecat3=2;

weight discwt;

title 'Logi Reg anyproc vs renalicd9 in MI patients with RACE +income  for stemi >=65';

run;

quit;

2 REPLIES 2
1zmm
Quartz | Level 8

You state that the value of an unstratified odds ratio should be between the values of its component stratified odds ratios.  This is not true, as the following set of 2-by-2 tables shows:

                       10      10                                2          1                            12    11

                         1         2                             10        10                            11    12

  odds ratio         2.00                                      2.00                                  1.19

Ashwini_uci
Obsidian | Level 7

Thanks for your response. But this was pointed out by one of the reviewers from a very reputed Journal as a part of the manuscript review process. That is when I started wondering if it is really true/correct to have unstratified OR somewhere between the 2 startified ORs.

I tried with a couple of examples as you have shown above and I too didnot get the OR value in between its component stratified ORs .

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