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04-25-2016 10:43 PM

So I am trying to replicate this statement in SAS (basically to come up with the 300 patients part), but I can't seem to figure out how:

60% of the patients will be considered adherent, 300 patients will allow an AUC of 0.80 to be estimated with an accuracy (i.e. half width of the 95% confidence interval) of 0.049

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04-26-2016 09:57 AM

Some things to consider. AUC is likely lognormally distributed. Iget something like this from:

```
proc power;
OneSampleMeans test = t Dist = LogNormal
Alpha = 0.05
Sides = 2
Mean = 0.8
NullMean = 0.79
CV = 0.06125
Power = 0.8
NTotal = .
;
```

Where I got the CV as .049/0.8.

This may just be coincidental, though.

Steve Denham