Programming the statistical procedures from SAS

How do I do a sample size calculation based on AUC in SAS?

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How do I do a sample size calculation based on AUC in SAS?

So I am trying to replicate this statement in SAS (basically to come up with the 300 patients part), but I can't seem to figure out how:

60% of the patients will be considered adherent, 300 patients will allow an AUC of 0.80 to be estimated with an accuracy (i.e. half width of the 95% confidence interval) of 0.049

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Posts: 2,655

Re: How do I do a sample size calculation based on AUC in SAS?

Some things to consider.  AUC is likely lognormally distributed.  Iget something like this from:

proc power;
   OneSampleMeans test = t Dist = LogNormal
      Alpha = 0.05
      Sides = 2
      Mean = 0.8
      NullMean = 0.79
      CV = 0.06125
      Power = 0.8
      NTotal = .
   ;

Where I got the CV as .049/0.8.

 

This may just be coincidental, though.

 

Steve Denham

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