I am not a statistician. I would greatly appreciate if some body could give me some suggestions for my following data analysis.
I have an experiment in which 12 mice from 3 genotypes were treated by a drug and followed 3 timepoints (pre-treatment, 48hr, 96hr, and 1wk) after the treatment. I randomly took 6 hairs from each mouse at each timepoint to measure the expressions of one gene in the follicels (e.g., 6 biological replicates per mouse per time point). I am trying to find 1) whether the gene expressions were affected by the drug no matter the mouse genotype is; 2) whether there is an effect of genotype on the drug response. I thought this might be a repeated measurement experiment and tried to use the Proc Mixed with the repeated option (with timepoints as repeated and subjuect=mouseID). Since each mouse at each timepoint have 6 bioligical replicates, I don't know how to handle this replicates in the Proc Mixed. My SAS code is: