Programming the statistical procedures from SAS

Covariate balance randomized trials

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Contributor
Posts: 73

Covariate balance randomized trials

Hi, this may a question posted the wrong forum but I trying here.

 

If patients are randomzied in a clinical trial one is expecting that both measured and unmeasured baseline covariates are balanced between treated and controls.

 

My question is how you mathematically/statisticaly can derive that balance is increased when the study popualtion is increasing?

 

Thanks in advance!

Thomas

 

Respected Advisor
Posts: 4,606

Re: Covariate balance randomized trials

In my mind, it goes like this.

Because of randomisation, the expected value of both control and treated groups are the same for all covariates. When the sample sizes increase, the standard errors of estimated means decrease. Thus the expected difference between treated and control group means decreases.

PG
Contributor
Posts: 73

Re: Covariate balance randomized trials

Thank you PGStats for your quick reply!

/Thomas

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