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How do i write a model statement for drug release kinetics

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Occasional Contributor
Posts: 8

How do i write a model statement for drug release kinetics

I want to write a SAS syntax and run an analysis to evaluate the release of drug in an in vitro system across time periods. 

I intend to use the First order and HIguchi model equations to get values of release constant.

The equations are 

First Order: C = Coe(-kt)

Higuchi model : Mt / M∞ = Ktn (n is a superscript).

I would be grateful for any help.

Here is the syntax i was trying to develop:

 

DATA RELEASE;
Input TIME IVR SPECIES$;
Cards;
0.5       25.23453368 RCT

1          42.27780807 RCT

2          57.41862589 RCT

4          66.45725747 RCT

8          73.90717437 RCT

12        76.55205776 RCT

24        80.6309246 RCT

0.5       26.7912474 GCT

1          32.34728724 GCT

2          43.19154218 GCT

4          58.16394836 GCT

8          66.98968011 GCT

12        71.2555386 GCT

24        74.88005282 GCT

;

PROC SORT DATA = WORK.RELEASE;
BY SPECIES;
RUN;
PROC PLOT DATA = WORK.RELEASE;
BY SPECIES;
RUN;

 

 

Respected Advisor
Posts: 4,930

Re: How do i write a model statement for drug release kinetics

Posted in reply to FestusAdejoro

Use proc NLIN to fit your equations.

 

It is not clear what is the relationship between IVR, Mt and C.

 

PG
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