time-vary exposed/unexposed medication analysis ?

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time-vary exposed/unexposed medication analysis ?

Because both the dose and duration of medication vary between and within individual over time.

Exposure: once a user always a user or how to define where they censored

Non exposure: How do we handle unexposed persons who later became exposed to medication?

Is there any other methods to analyses or explain to how magnitude of reconciliation (or continuity) of exposed drug ?

How do we handle the time-vary drugs dispensed?  Should we use the time-dependent Cox model by classifying time-vary medication exposure

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