topic Re: Is there any procedure for cure model? in Statistical Procedures

Is there any procedure for cure model?

TomHsiung — Fri, 29 Aug 2025 13:48:54 GMT

Cure model is a kind of survival analysis model. It assume some observations are "statistical cure", who are not able to experience the endpoint event of interest. I don't know if this type of analysis is supported by standard SAS procedures. Thank you.

Re: Is there any procedure for cure model?

ChrisHemedinger — Fri, 29 Aug 2025 15:20:27 GMT

This project might be of interest:

GitHub - zjph602xtc/mixture-cure-model: This is a fork of Pierre JOLY's mixture cure model SAS macro, which is publicly available.

It contains thorough documentation so you can evaluate.

Re: Is there any procedure for cure model?

SAS_Rob — Fri, 29 Aug 2025 15:36:22 GMT

Cure rate models can be done in SAS in the context of the fitting a Gompertz Distribution. The usage note linked below describes some of the options as far as fitting these models in SAS is concerned.

24452 - Using the Gompertz distribution when fitting a model in PROC LIFEREG

Re: Is there any procedure for cure model?

TomHsiung — Sun, 31 Aug 2025 15:34:52 GMT

@ChrislHemedinger and @SAS_Rob Hey, guys

Thanks a bunch for your response. I know there are some MACRO but I am not sure if the follow the maximum likelihood method for the cure model.

I read from a book that the likelihood function of a cure model include a mixture of a logistic and a Cox model. I really wish the SAS can have a procedure to handle this type of survival analysis because I see its academic potential in evidence-based medicine, especially cancer, etc.

The likelihood function is below and it simply follows the partial likelihood function of a regular survival analysis model.

Re: Is there any procedure for cure model?

Ksharp — Mon, 01 Sep 2025 07:41:37 GMT

Maybe @Rick_SAS could give you a hand.

Re: Is there any procedure for cure model?

TomHsiung — Wed, 03 Sep 2025 11:53:03 GMT

The source of the likelihood function of a cure model above also lists the PSPMCM macro as the solution for the mixture survival model.