topic Re: nonmem sample program in Statistical Procedures

nonmem sample program

magicdj — Fri, 10 May 2024 16:52:06 GMT

refer to an old post below. i searched , but can't find any sample program. can anyone post a specific link for sample program? thanks.

Solved: Nonmem Program - SAS Support Communities

Re: nonmem sample program

PaigeMiller — Fri, 10 May 2024 16:59:33 GMT

According to that link you gave, @SteveDenham says that there are examples with code in the SAS documentation. Are you not able to find them?

Re: nonmem sample program

ballardw — Fri, 10 May 2024 17:02:31 GMT

The online help for the procedure NLMIXED has 7 example programs in the Examples tabs.

If none of those match your needs then you need to describe your specific model need and be prepared to share some data that will behave in a manner similar to your actual data.

Re: nonmem sample program

magicdj — Fri, 10 May 2024 17:04:29 GMT

nope, i can't find, that's why i ask if anyone has a specific link for that.

Re: nonmem sample program

magicdj — Fri, 10 May 2024 17:07:45 GMT

is this what you talking about?

Re: nonmem sample program

PaigeMiller — Fri, 10 May 2024 17:14:30 GMT

@magicdj wrote:

nope, i can't find, that's why i ask if anyone has a specific link for that.

Google will find it easily

Re: nonmem sample program

ballardw — Fri, 10 May 2024 17:18:16 GMT

Yes.

Re: nonmem sample program

Reeza — Fri, 10 May 2024 17:50:57 GMT

The documentation link is here.

https://documentation.sas.com/doc/en/statug/15.2/statug_nlmixed_examples.htm

You can click the full code under each example title for the full code for each example as they sometimes leverage datasets from previous examples or just have the more lines in the code. Not sure how the built in documentation from your screenshot works.

Re: nonmem sample program

sbxkoenk — Sun, 12 May 2024 12:48:21 GMT

Is your question in the realm of population pharmacokinetics/pharmacodynamics (pop PK/PD) analysis used in Clinical Pharmacology research? Or are you talking about Nonlinear Mixed Effects Modeling (NONMEM) in general?
Are you comparing the NONMEM software (ICON Development Solutions) to SAS/Stat PROC NLMIXED?
Do you need Ordinary Differential Equations (ODE)?
Are you fitting compartment Models? If yes, how many compartments?
Which specific dosing (aka forcing functions) do you need?

If you give a bit more insight in your use case, then the answers provided will be more insightful for you as well.

Koen

Re: nonmem sample program

magicdj — Sun, 12 May 2024 17:48:07 GMT

will be used for realm of population pharmacokinetics/pharmacodynamics (pop PK/PD) analysis used in Clinical Pharmacology research. rest of your questions are not apply

Re: nonmem sample program

sbxkoenk — Sun, 12 May 2024 20:26:56 GMT

SAS/STAT 15.3 User's Guide
The NLMIXED Procedure

Example 89.1 One-Compartment Model with Pharmacokinetic Data
https://go.documentation.sas.com/doc/en/pgmsascdc/9.4_3.5/statug/statug_nlmixed_examples01.htm
Details --> Compartment Models
https://go.documentation.sas.com/doc/en/pgmsascdc/9.4_3.5/statug/statug_nlmixed_details07.htm
Syntax --> CMPTMODEL Statement
https://go.documentation.sas.com/doc/en/pgmsascdc/9.4_3.5/statug/statug_nlmixed_syntax05.htm

The MCMC Procedure (Bayesian nonmem)

Example 79.22 One-Compartment Model with Pharmacokinetic Data
https://go.documentation.sas.com/doc/en/pgmsascdc/9.4_3.5/statug/statug_mcmc_examples31.htm

Moreover SAS can do : Non-Compartmental (Model Independent) methods (but no examples found in doc)!

Also, ... found an old paper (2007) ... probably still useful.

Paper 148-2007
Population Pharmacokinetics Studies with Nonlinear Mixed Effects Modeling
David Shen, Alps Biostatistics Inc. ; Zaizai Lu, AstraZeneca Pharmaceuticals
https://support.sas.com/resources/papers/proceedings/proceedings/forum2007/148-2007.pdf

Good luck,

Koen