topic Re: Simulations for Clinical Trials in Statistical Procedures

Simulations for Clinical Trials

shridula95 — Sun, 14 Feb 2021 14:11:11 GMT

Hello

I am trying to run a simulation, based on 1000 replications, with sample size=50 for the imbalance (Dn) and predictability of a sequence (Ppred) in Clinical Studies Design. Some of the randomization procedures for which the simulation has to be run are 1)Complete Randomization 2)Permuted block design, with block size=4, etc.

Any help with how to write the SAS code for these simulation procedures is highly appreciated!

Re: Simulations for Clinical Trials

Rick_SAS — Mon, 15 Feb 2021 17:14:44 GMT

Is this for a course? What have you learned so far about how to generate a random design?

You can use the GROUPS= option in PROC SURVEYSELECT to randomly assign subjects to groups. (Placebo, treatment1, treatment2, etc.) See this note.

For more advanced designs, you might look at PROC PLAN.

Re: Simulations for Clinical Trials

shridula95 — Tue, 16 Feb 2021 07:16:45 GMT

Thank you, I will check out these links.

Yes, It is for a course I am taking. So far I've learnt how to use the ranuni function to generate a random list and also how to set a seed/call a seed for generating random numbers.